Retrospective analysis of Steven Johnson syndrome and toxic epidermal necrolysis over a period of 5 years from northern Karnataka, India

被引：16

作者：

Naveen, Kikkeri Narayanasetty ^{[1
]}

Pai, Varadraj V. ^{[1
]}

Rai, Vijetha ^{[1
]}

Athanikar, Sharatchandra B. ^{[1
]}

机构：

[1] Sri Dharmasthala Manjunatheshwara Coll Med Sci &, Dept Dermatol, Dharwad, Karnataka, India

来源：

INDIAN JOURNAL OF PHARMACOLOGY | 2013年 / 45卷 / 01期

关键词：

Anti-epileptics; ofloxacin; Stevens Johnson syndrome; toxic epidermal necrosis; ERYTHEMA MULTIFORME; CAUSATIVE AGENTS; S[!text type='JS']JS[!/text]-10 OVERLAP; DRUG-REACTIONS; CLINICAL TYPES; INPATIENTS; RISK;

D O I：

10.4103/0253-7613.106441

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN). Materials and Methods: A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN. Results: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin. Conclusion: SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.

引用

页码：80 / 82

页数：3

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