The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

被引：552

作者：

Zitvogel, Laurence ^{[1
,2
,3
,4
]}

Ma, Yuting ^{[5
,6
,7
]}

Raoult, Didier ^{[8
]}

Kroemer, Guido ^{[9
,10
,11
]}

Gajewski, Thomas F. ^{[12
,13
]}

机构：

[1] GRCC, Equipe Labellisee Ligue Natl Canc, Villejuif, France

[2] INSERM, U1015, Villejuif, France

[3] Univ Paris Sud, Univ Paris Saclay, Gustave Roussy, Villejuif, France

[4] Ctr Clin Invest Biotherapies Canc CICBT 1428, Villejuif, France

[5] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[6] Peking Union Med Coll, Beijing 100005, Peoples R China

[7] Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China

[8] Aix Marseille Univ, Unite Rech Malad Infect & Trop Emergentes, Inst Hosp Univ IHU Mediterranee Infect, UM63,CNRS 7278,IRD 198,INSERM 1095, 19-21 Blvd Jean Moulin, F-13005 Marseille, France

[9] Univ Paris 05, Univ Pierre & Marie Curie, Ctr Rech Cordeliers, Sorbonne Paris Cite, Paris, France

[10] GRCC, Metabol & Cell Biol Platforms, Villejuif, France

[11] Equipe 11 Labellisee Ligue Natl Canc, UMRS 1138, Paris, France

[12] Univ Chicago, Dept Med, Dept Pathol, Chicago, IL 60615 USA

[13] Univ Chicago, Ben May Dept Canc, Chicago, IL 60615 USA

来源：

SCIENCE | 2018年 / 359卷 / 6382期

基金：

欧洲研究理事会;

关键词：

FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ENTEROCOCCUS-HIRAE; RESISTANCE; ANTITUMOR; IMMUNITY; BACTERIA; DISEASE;

D O I：

10.1126/science.aar6918

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The fine line between human health and disease can be driven by the interplay between host and microbial factors. This "metagenome" regulates cancer initiation, progression, and response to therapies. Besides the capacity of distinct microbial species to modulate the pharmacodynamics of chemotherapeutic drugs, symbiosis between epithelial barriers and their microbial ecosystems has a major impact on the local and distant immune system, markedly influencing clinical outcome in cancer patients. Efficacy of cancer immunotherapy with immune checkpoint antibodies can be diminished with administration of antibiotics, and superior efficacy is observed with the presence of specific gut microbes. Future strategies of precision medicine will likely rely on novel diagnostic and therapeutic tools with which to identify and correct defects in the microbiome that compromise therapeutic efficacy.

引用

页码：1366 / 1370

页数：5

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