Thiamine hydrochloride (VB1) as an efficient promoter for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones

被引：56

作者：

Chen, Yijia ^{[2
]}

Shan, Weiguang ^{[2
]}

Lei, Min ^{[1
]}

Hu, Lihong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 44期

基金：

中国国家自然科学基金;

关键词：

Thiamine hydrochloride (VB1); Isatoic anhydride; Aldehyde; Dihydroquinazolin-4(1H)-one; Green chemistry; DERIVATIVES; WATER; ALDEHYDES; CATALYST;

D O I：

10.1016/j.tetlet.2012.08.090

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile, efficient, and environmentally friendly procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from isatoic anhydride, aldehyde, and ammonium acetate in the presence of thiamine hydrochloride (VB1) in EtOH is described. The protocol proves to be efficient and environmentally benign in terms of high yields, ease of recovery, and reusability of catalyst. (C) 2012 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5923 / 5925

页数：3

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