Conformation Model of Back-Folding and Looping of a Single DNA Molecule Confined Inside a Nanochannel

被引：50

作者：

Dai, Liang ^{[2
]}

Ng, Siow Yee ^{[1
]}

Doyle, Patrick S. ^{[2
,3
]}

van der Maarel, Johan R. C. ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore

[2] Singapore MIT Alliance Res & Technol, Singapore, Singapore

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ACS MACRO LETTERS | 2012年 / 1卷 / 08期

基金：

美国国家科学基金会;

关键词：

STATISTICS; POLYMERS; COMPACTION;

D O I：

10.1021/mz300323a

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Currently, no theory is available to describe,the conformation of DNA confined in a channel when the nanochannel diameter is around the persistence length. Back-folded hairpins in the undulating wormlike chain conformation result in the formation of loops, which reduces the stretch of the molecule in the longitudinal direction of the channel. A Cooperativity Model is used to quantify the frequency and size of the loop domains. The predictions agree with results from the Monte Carlo simulation.

引用

页码：1046 / 1050

页数：5

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