Anti-infliximab antibodies in inflammatory bowel disease: prevalence, infusion reactions, immunosuppression and response, a meta-analysis
被引:63
作者:
Lee, Lennard Y. W.
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Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
Lee, Lennard Y. W.
[1
]
Sanderson, Jeremy D.
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Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
Sanderson, Jeremy D.
[1
]
Irving, Peter M.
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Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, EnglandGuys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
Irving, Peter M.
[1
]
机构:
[1] Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England
Infliximab is a chimeric monoclonal antibody directed against tumour necrosis factor-alpha. When used in inflammatory bowel disease, primary nonresponse is found in at least 10% of patients, with secondary loss of response occurring in a further 10-15% per year. It has been suggested that this may in part be a result of the development of anti-infliximab antibodies (ATIs). The aim of the study was to determine in patients receiving infliximab the prevalence of ATIs, the effect of immunosuppressants on the prevalence of ATI, the effect of ATIs on the prevalence of infusion reactions and the effect of ATIs on the rates of remission. MEDLINE and EMBASE databases were searched from 1948 and 1980, respectively, to October 2011. Eighteen studies involving 3326 patients were included. The prevalence of ATIs was 45.8% when episodic infusions of infliximab were given and 12.4% when maintenance infliximab was given. The rates of infusion reactions were significantly higher in patients with ATIs (relative risk: 2.07; 95% confidence interval, 1.61-2.67). Immunosuppressants resulted in a 50% reduction in the risk of developing ATIs (P<0.00001). However, the presence or absence of ATIs did not affect the rates of clinical remission. The prevalence of ATIs depends on the regimen of infliximab administration and the use of immunosuppressants. Patients who test positive for ATIs are at an increased risk of infusion reactions, but have similar rates of remission compared with patients who test negative for ATIs. Further analysis is required to determine whether loss of response is dependent on the titre of ATIs. Eur J Gastroenterol Hepatol 24: 1078-1085 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Ben-Horin, Shomron
;
Yavzori, Miri
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Yavzori, Miri
;
Katz, Lior
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Katz, Lior
;
Kopylov, Uri
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Kopylov, Uri
;
Picard, Orit
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Picard, Orit
;
Fudim, Ella
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Fudim, Ella
;
Coscas, Daniel
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Coscas, Daniel
;
Bar-Meir, Simon
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Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Bar-Meir, Simon
;
Goldstein, Itamar
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机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Goldstein, Itamar
;
Chowers, Yehuda
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机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
机构:
Univ Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Univ Lille Nord France, CHU Lille, Ctr Invest Clin, F-59037 Lille, FranceUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Colombel, Jean Frederic
;
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Rochester, MN USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Sandborn, William J.
;
Reinisch, Walter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Vienna, Vienna, AustriaUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Reinisch, Walter
;
Mantzaris, Gerassimos J.
论文数: 0引用数: 0
h-index: 0
机构:
Evangelismos Med Ctr, Athens, GreeceUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Mantzaris, Gerassimos J.
;
Kornbluth, Asher
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Med Ctr, New York, NY 10029 USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Kornbluth, Asher
;
Rachmilewitz, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Jerusalem, IsraelUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Rachmilewitz, Daniel
;
Lichtiger, Simon
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Med Ctr, New York, NY 10029 USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Lichtiger, Simon
;
D'Haens, Geert
论文数: 0引用数: 0
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机构:
Imelda Ziekenhuis, Bonheiden, BelgiumUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
D'Haens, Geert
;
Diamond, Robert H.
论文数: 0引用数: 0
h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Diamond, Robert H.
;
Broussard, Delma L.
论文数: 0引用数: 0
h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Broussard, Delma L.
;
Tang, Kezhen L.
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h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Tang, Kezhen L.
;
van der Woude, C. Janneke
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h-index: 0
机构:
Erasmus MC, Rotterdam, NetherlandsUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
van der Woude, C. Janneke
;
Rutgeerts, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Gasthuisberg, B-3000 Leuven, BelgiumUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Ben-Horin, Shomron
;
Yavzori, Miri
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Yavzori, Miri
;
Katz, Lior
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Katz, Lior
;
Kopylov, Uri
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Kopylov, Uri
;
Picard, Orit
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Picard, Orit
;
Fudim, Ella
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机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Fudim, Ella
;
Coscas, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Coscas, Daniel
;
Bar-Meir, Simon
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Bar-Meir, Simon
;
Goldstein, Itamar
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
Goldstein, Itamar
;
Chowers, Yehuda
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Gastroenterol, Chaim Sheba Med Ctr, Tel Hashomer & Sackler Sch Med, IL-69978 Tel Aviv, Israel
机构:
Univ Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Univ Lille Nord France, CHU Lille, Ctr Invest Clin, F-59037 Lille, FranceUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Colombel, Jean Frederic
;
Sandborn, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Rochester, MN USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Sandborn, William J.
;
Reinisch, Walter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Vienna, Vienna, AustriaUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Reinisch, Walter
;
Mantzaris, Gerassimos J.
论文数: 0引用数: 0
h-index: 0
机构:
Evangelismos Med Ctr, Athens, GreeceUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Mantzaris, Gerassimos J.
;
Kornbluth, Asher
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Med Ctr, New York, NY 10029 USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Kornbluth, Asher
;
Rachmilewitz, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Jerusalem, IsraelUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Rachmilewitz, Daniel
;
Lichtiger, Simon
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Med Ctr, New York, NY 10029 USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Lichtiger, Simon
;
D'Haens, Geert
论文数: 0引用数: 0
h-index: 0
机构:
Imelda Ziekenhuis, Bonheiden, BelgiumUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
D'Haens, Geert
;
Diamond, Robert H.
论文数: 0引用数: 0
h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Diamond, Robert H.
;
Broussard, Delma L.
论文数: 0引用数: 0
h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Broussard, Delma L.
;
Tang, Kezhen L.
论文数: 0引用数: 0
h-index: 0
机构:
Centocor Ortho Biotech, Malvern, PA USAUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
Tang, Kezhen L.
;
van der Woude, C. Janneke
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus MC, Rotterdam, NetherlandsUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France
van der Woude, C. Janneke
;
Rutgeerts, Paul
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Gasthuisberg, B-3000 Leuven, BelgiumUniv Lille Nord France, CHU Lille, Hop Claude Huriez, F-59037 Lille, France