Synthesis, characterization, and antibacterial activity of three palladium(II) complexes of tetracyclines

被引：80
作者：
Guerra, W
Azevedo, ED
Monteiro, ARD
Bucciarelli-Rodriguez, M
Chartone-Souza, E
Nascimento, AMA
Fontes, APS
Le Moyec, L
Pereira-Maia, EC
机构：
[1] Univ Fed Minas Gerais, Dept Quim ICEx, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Biol Geral ICB, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Juiz Fora, Dept Quim ICE, Juiz De Fora, MG, Brazil
[4] Univ Paris 13, Lab BioMoCeTi, F-93017 Bobigny, France
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 12期
关键词：
synthesis; tetracyclines; palladium complexes; antimicrobial activity; bacterial resistance;
D O I：
10.1016/j.jinorgbio.2005.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pd(II) complexes with three antibiotics of the tetracycline family (tetracycline, doxycycline and chlortetracycline) were synthesized and characterized by elemental, thermogravimetric, and conductivity analyses, and infrared spectroscopy. The interactions between Pd(II) ions and tetracycline were investigated in aqueous solution by H-1 NMR. All the tetracyclines studied form 1:1 complexes with Pd(II) via the oxygen of the hydroxyl group at ring A and that of the amide group. The effect of the three complexes on the growth of bacterial strains sensitive and resistant to tetracycline was studied. The Pd(II) complex of tetracycline is practically as efficient as tetracycline in inhibiting the growth of two Escherichia coli (E. coli) sensitive bacterial strains and 16 times more potent against E coli HB101/pBR322, a bacterial strain resistant to tetracycline. Pd(II) coordination to doxycycline also increased its activity in the resistant strain by a factor of 2. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：2348 / 2354
页数：7
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