Establishment and characterization of a human adenoid cystic carcinoma line of the salivary gland which is serially transplantable and spontaneously metastasises to the lung in nude mice

被引：15

作者：

Umeda, M ^{[1
]}

Komatsubara, H ^{[1
]}

Nishimatsu, N ^{[1
]}

Oku, N ^{[1
]}

Shibuya, Y ^{[1
]}

Yokoo, S ^{[1
]}

Komori, T ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

ORAL ONCOLOGY | 2002年 / 38卷 / 01期

关键词：

adenoid cystic carcinoma; transplantation; nude mice; lung metastasis;

D O I：

10.1016/S1368-8375(01)00010-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the head and neck occurring in the salivary glands. We established a human ACC line which is serially transplantable in nude mice and designated it as KOA-1. The KOA-1 tumour doubled in 9.3 dabs and retained the histological characteristics of a solid pattern of ACC even after 22 serial passages, The KOA-1 metastasised to the lung when transplanted subcutaneously into the back. This tumour line may serve as a useful model for exploration of the biological behaviour and treatment of human ACC. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：30 / 34

页数：5

共 13 条

[1]

HADDAD A, 1995, J OTOLARYNGOL, V24, P201

[2] DEVELOPMENT OF A NEW INVASION AND METASTASIS MODEL OF HUMAN ORAL SQUAMOUS-CELL CARCINOMAS [J].

KAWASHIRI, S ;

KUMAGAI, S ;

KOJIMA, K ;

HARADA, H ;

YAMAMOTO, E .

ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B, 1995, 31B (04) :216-221

[3]

LI SL, 1990, CHUNG HUA KOU CHIANG, V25, P29

[4] CERVICOFACIAL ADENOID CYSTIC CARCINOMA - STUDY OF 102 CASES - INFLUENCE OF RADIATION-THERAPY [J].

MIGLIANICO, L ;

ESCHWEGE, F ;

MARANDAS, P ;

WIBAULT, P .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1987, 13 (05) :673-678

[5] INFLUENCE OF ORGAN ENVIRONMENT ON EXTRACELLULAR-MATRIX DEGRADATIVE ACTIVITY AND METASTASIS OF HUMAN COLON-CARCINOMA CELLS [J].

NAKAJIMA, M ;

MORIKAWA, K ;

FABRA, A ;

BUCANA, CD ;

FIDLER, IJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (24) :1890-1898

[6]

NISHIMATSU N, 1997, J JPN SOC ORAL TUMOR, V9, P81

[7]

PERZIN KH, 1978, CANCER, V42, P265, DOI 10.1002/1097-0142(197807)42:1<265::AID-CNCR2820420141>3.0.CO

[8]

2-Z

[9]

SHIRASUNA K, 1993, CANCER RES, V53, P147

[10] ESTABLISHMENT OF A CELL-LINE PRODUCING BASEMENT-MEMBRANE COMPONENTS FROM AN ADENOID CYSTIC CARCINOMA OF THE HUMAN SALIVARY-GLAND [J].

SOBUE, M ;

TAKEUCHI, J ;

NIWA, M ;

YASUI, C ;

NAKAGAKI, S ;

NAGASAKA, T ;

FUKATSU, T ;

SAGA, S ;

NAKASHIMA, N .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1989, 57 (03) :203-208

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