Clinical Significance of Basal-like Breast Cancer in Chinese Women in Heilongjiang Province

被引：4

作者：

Liu, Ying ^{[1
]}

Jiang, Qiu-Ying ^{[1
]}

Xin, Tao ^{[1
]}

Cai, Li ^{[2
]}

Zhao, Chang-Hong ^{[2
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Oncol Hosp, Dept Oncol, Harbin, Heilongjiang, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 06期

关键词：

Basal like; breast cancer; prognosis; TRIPLE-NEGATIVE PHENOTYPE; PROGNOSTIC VALUE; EXPRESSION; CARCINOMA; SUBTYPES; MARKERS; BMI-1;

D O I：

10.7314/APJCP.2012.13.6.2735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1(Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE-in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.

引用

页码：2735 / 2738

页数：4

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