Synthesis and Cytotoxic Evaluation of 2-O-alkyl Derivatives of L-Ascorbic Acid

被引：0
|
作者：
Dengale, Rohit A. [1 ]
Thopate, Shankar R. [1 ]
机构：
[1] Ahmednagar Coll, Dept Chem, Ahmednagar, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 04期
关键词：
Alkylation; L-Ascorbic acid derivatives; Cytotoxicity; Desilylation; One-pot synthesis; Silylation; LIPID-PEROXIDATION; INHIBITORS; CELLS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of both 5,6-O-protected and unprotected 2-O-alkyl derivatives of l-ascorbic acid were synthesized using silylation-alkylation-desilylation sequence in a one-pot manner. These derivatives were screened for their anticancer activity against human breast cancer cell line (MCF-7) and exhibited decent cytotoxicity.
引用
收藏
页码：395 / 399
页数：5
相关论文
共 50 条
  • [41] 2-Keto-L-Gulonic Acid Improved the Salt Stress Resistance of Non-heading Chinese Cabbage by Increasing L-Ascorbic Acid Accumulation
    Gao, Mingfu
    Sun, Hao
    Shi, Meijun
    Wu, Qiqi
    Ji, Dongxu
    Wang, Bing
    Zhang, Lixin
    Liu, Yang
    Han, Litao
    Ruan, Xicheng
    Xu, Hui
    Yang, Weichao
    FRONTIERS IN PLANT SCIENCE, 2021, 12
  • [42] Synthesis and Cytotoxic Evaluation for Some New Dihydropyrimidinone Derivatives for Anticancer Activity
    Reddy, Onteddu Surendranatha
    Suryanarayana, Ch Venkata
    Sharmila, N.
    Ramana, G. V.
    Anuradha, V.
    Babu, B. Hari
    LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (08) : 699 - 705
  • [43] Regioselective synthesis of 3-O-alkyl ethers of ascorbic acid without protecting groups in a single step
    Beifuss, U
    Kunz, O
    Voss, G
    TETRAHEDRON, 2000, 56 (03) : 357 - 361
  • [44] Synthesis, characterization, and evaluation of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing effects of copper nanoparticles using the aqueous extract of Strawberry fruit and L-Ascorbic acid
    Hemmati, Saba
    Ahmeda, Ahmad
    Salehabadi, Yaser
    Zangeneh, Akram
    Zangeneh, Mohammad Mahdi
    POLYHEDRON, 2020, 180
  • [45] Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives
    Song, Panpan
    Cui, Fei
    Li, Na
    Xin, Jingchao
    Ma, Qisheng
    Meng, Xiangchuan
    Wang, Chaojie
    Cao, Qinpo
    Gu, Yifei
    Ke, Yu
    Zhang, Qiurong
    Liu, Hongmin
    CHINESE JOURNAL OF CHEMISTRY, 2017, 35 (10) : 1633 - 1639
  • [46] Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives
    M. E. Rakhmanova
    O. A. Luzina
    M. A. Pokrovskii
    A. G. Pokrovskii
    N. F. Salakhutdinov
    Russian Chemical Bulletin, 2016, 65 : 566 - 569
  • [47] Synthesis and Biological Activity of Novel O-Alkyl Derivatives of Naringenin and Their Oximes
    Kozlowska, Joanna
    Potaniec, Bartlomiej
    Zarowska, Barbara
    Aniol, Miroslaw
    MOLECULES, 2017, 22 (09):
  • [48] Design, synthesis, and cytotoxic evaluation of novel scopoletin derivatives
    Shi, Wei
    Zhang, Jinlu
    Bao, Na
    Guan, Fuqin
    Chen, Li
    Sun, Jianbo
    CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 91 (02) : 641 - 646
  • [49] Synthesis and Cytotoxic Evaluation of Some New Phthalazinylpiperazine Derivatives
    Liu, Yajing
    Zhang, Shulan
    Li, Ye
    Wang, Jianqiang
    Song, Yu
    Gong, Ping
    ARCHIV DER PHARMAZIE, 2012, 345 (04) : 287 - 293
  • [50] Synthesis and evaluation of cytotoxic effects of hanultarin and its derivatives
    Lee, Eunyoung
    Ahamed, V. S. Jamal
    Kumar, Mahto Sanjeev
    Rhee, Seog Woo
    Moon, Surk-Sik
    Hong, In Seok
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) : 6245 - 6248
12345