Synthesis and Cytotoxic Evaluation of 2-O-alkyl Derivatives of L-Ascorbic Acid

被引：0

作者：

Dengale, Rohit A. ^{[1
]}

Thopate, Shankar R. ^{[1
]}

机构：

[1] Ahmednagar Coll, Dept Chem, Ahmednagar, Maharashtra, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 04期

关键词：

Alkylation; L-Ascorbic acid derivatives; Cytotoxicity; Desilylation; One-pot synthesis; Silylation; LIPID-PEROXIDATION; INHIBITORS; CELLS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of both 5,6-O-protected and unprotected 2-O-alkyl derivatives of l-ascorbic acid were synthesized using silylation-alkylation-desilylation sequence in a one-pot manner. These derivatives were screened for their anticancer activity against human breast cancer cell line (MCF-7) and exhibited decent cytotoxicity.

引用

页码：395 / 399

页数：5

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