Synthesis and Cytotoxic Evaluation of 2-O-alkyl Derivatives of L-Ascorbic Acid

被引：0
|
作者：
Dengale, Rohit A. [1 ]
Thopate, Shankar R. [1 ]
机构：
[1] Ahmednagar Coll, Dept Chem, Ahmednagar, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 04期
关键词：
Alkylation; L-Ascorbic acid derivatives; Cytotoxicity; Desilylation; One-pot synthesis; Silylation; LIPID-PEROXIDATION; INHIBITORS; CELLS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of both 5,6-O-protected and unprotected 2-O-alkyl derivatives of l-ascorbic acid were synthesized using silylation-alkylation-desilylation sequence in a one-pot manner. These derivatives were screened for their anticancer activity against human breast cancer cell line (MCF-7) and exhibited decent cytotoxicity.
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收藏
页码：395 / 399
页数：5
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