Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain

被引：7

作者：

Saleh Velez, Faddi G. ^{[1
,2
,3
]}

Pinto, Camila B. ^{[1
,2
,4
]}

Bailin, Emma S. ^{[5
]}

Munger, Marionna ^{[1
,2
]}

Ellison, Andrew ^{[6
]}

Costa, Beatriz T. ^{[1
,2
]}

Crandell, David ^{[7
]}

Bolognini, Nadia ^{[8
,9
,10
]}

Merabet, Lotfi B. ^{[5
]}

Fregni, Felipe ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Lab Neuromodulat, Dept Phys Med & Rehabil, Spaulding Rehabil Hosp, Boston, MA 02115 USA

[2] Harvard Med Sch, Ctr Clin Res Learning, Dept Phys Med & Rehabil, Spaulding Rehabil Hosp, Boston, MA 02115 USA

[3] Univ Chicago, Med Ctr, Dept Neurol, Chicago, IL 60637 USA

[4] Univ Sao Paulo, Dept Neurosci & Behav, Psychol Inst, Sao Paulo, Brazil

[5] Harvard Med Sch, Lab Visual Neuroplast, Dept Ophthalmol, Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA

[6] Boston Univ, Sch Med, Ctr Biomed Imaging, Dept Anat & Neurobiol, Boston, MA 02215 USA

[7] Harvard Med Sch, Spaulding Rehabil Hosp, Boston, MA 02115 USA

[8] Univ Milano Bicocca, Dept Psychol, Milan, Italy

[9] Univ Milano Bicocca, Milan Ctr Neurosci, Milan, Italy

[10] Ist Auxol Italiano, IRCCS, Neuropsychol Lab, Milan, Italy

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2019年 / 146期

关键词：

Neuroscience; Issue; 146; Phantom limb pain; fMRI; brain imaging; mirror therapy; amputation; neuroplasticity; sensorimotor cortex; EXTENSIVE REORGANIZATION; SOMATOSENSORY CORTEX; MOVEMENTS; SYSTEM; BRAIN; REHABILITATION;

D O I：

10.3791/58800

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mirror therapy (MT) has been proposed as an effective rehabilitative strategy to alleviate pain symptoms in amputees with phantom limb pain (PLP). However, establishing the neural correlates associated with MT therapy have been challenging given that it is difficult to administer the therapy effectively within a magnetic resonance imaging (MRI) scanner environment. To characterize the functional organization of cortical regions associated with this rehabilitative strategy, we have developed a combined behavioral and functional neuroimaging protocol that can be applied in participants with a leg amputation. This novel approach allows participants to undergo MT within the MRI scanner environment by viewing real-time video images captured by a camera. The images are viewed by the participant through a system of mirrors and a monitor that the participant views while lying on the scanner bed. In this manner, functional changes in cortical areas of interest (e.g., sensorimotor cortex) can be characterized in response to the direct application of MT.

引用

页数：8

共 45 条

[1]

Ambron E., 2018, FRONTIERS NEUROLOGY

[2] Crossmodal illusions in neurorehabilitation [J].