Endocannabinoid system and drug addiction: new insights from mutant mice approaches

被引：12

作者：

Maldonado, Rafael ^{[1
]}

Robledo, Patricia ^{[1
,2
]}

Berrendero, Fernando ^{[1
]}

机构：

[1] Univ Pompeu Fabra, Fac Hlth & Life Sci, Neuropharmacol Lab, Barcelona 08003, Spain

[2] IMIM Hosp Mar Med Res Inst, Neurosci Res Program, Human Pharmacol & Clin Neurosci Res Grp, Barcelona 08003, Spain

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2013年 / 23卷 / 04期

关键词：

CONDITIONED PLACE PREFERENCE; AMIDE HYDROLASE INHIBITION; NUCLEUS-ACCUMBENS DOPAMINE; ALCOHOL-CONSUMPTION; RECEPTOR; COCAINE; MORPHINE; DEPENDENCE; 2-ARACHIDONOYLGLYCEROL; RESPONSES;

D O I：

10.1016/j.conb.2013.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabinoid system components has now provided important advances in establishing their specific contribution to drug addiction. These genetic tools have identified the particular interest of CB1, cannabinoid receptor and endogenous anandamide as potential targets for drug addiction treatment. Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction.

引用

页码：480 / 486

页数：7

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