Cabergoline scavenges peroxynitrite enhanced by L-DOPA therapy in patients with Parkinson's disease

被引：10

作者：

Isobe, C ^{[1
]}

Abe, T ^{[1
]}

Kikuchi, T ^{[1
]}

Murata, T ^{[1
]}

Sato, C ^{[1
]}

Terayama, Y ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Neurol, Morioka, Iwate 020, Japan

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2006年 / 13卷 / 04期

关键词：

cabergoline; cerebrospinal fluid; L-DOPA; 3-nitrotyrosine; oxidative stress; Parkinson's disease; peroxynitrite;

D O I：

10.1111/j.1468-1331.2006.01207.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Long-term or high-dose L-DOPA therapy in patients with Parkinson's disease (PD) may accelerate degeneration of dopaminergic neurons, possibly by increasing oxidative stress. To investigate the effects of cabergoline on peroxynitrite-mediated oxidative damage caused by L-DOPA, the concentration of 3-nitrotyrosine in cerebrospinal fluid (CSF) of 18 PD patients was compared with that in 20 normal controls. The concentration of 3-nitrotyrosine in patients following L-DOPA therapy was significantly higher than in untreated PD patients and controls. On the other hand, the concentration in PD patients after cabergoline therapy was significantly lower than in PD patients after L-DOPA therapy alone. These data suggest that cabergoline scavenges peroxynitrite induced by L-DOPA in patients with PD.

引用

页码：346 / 350

页数：5

共 21 条

[1]

Acworth IN, 1999, METHOD ENZYMOL, V300, P297

[2]

BASMA AN, 1995, J NEUROCHEM, V64, P825

[3]

BEAL MF, 1995, J NEUROCHEM, V65, P919

[4] ALS, SOD AND PEROXYNITRITE [J].