HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma

被引：1
|
作者：
Reid, Erin [1 ]
Morris, Sheldon R. [2 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Hematol & Oncol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, Div Infect Dis, San Diego, CA 92103 USA
来源：
INFECTIOUS AGENTS AND CANCER | 2012年 / 7卷
关键词：
HIV; Non-hodgkins lymphoma; Co-receptor usage; CCR5; CXCR4; SDF-1; B-CELLS; CHEMOKINE; TROPISM; AIDS; EPIDEMIOLOGY; POPULATION; PREVALENCE; INFECTION; VIRUSES; RISK;
D O I：
10.1186/1750-9378-7-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV coreceptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04).
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页数：3
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