The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children

被引：21

作者：

Ansari, Marc ^{[1
,2
,7
]}

Uppugunduri, Chakradhara Rao S. ^{[1
,2
]}

Ferrari-Lacraz, Sylvie ^{[3
,4
]}

Bittencourt, Henrique ^{[5
]}

Gumy-Pause, Fabienne ^{[1
,2
]}

Chalandon, Yves ^{[1
]}

Tiercy, Jean-Marie ^{[3
,4
]}

Schechter, Tal ^{[6
]}

Gassas, Adam ^{[6
]}

Doyle, John D. ^{[6
]}

Dupuis, Lee ^{[6
]}

Duval, Michel ^{[5
]}

Krajinovic, Maja ^{[7
,8
]}

Villard, Jean ^{[3
,4
]}

机构：

[1] Univ Hosp Geneva, Dept Pediat, Oncohematol Unit, Geneva, Switzerland

[2] Geneva Med Univ, CANSEARCH Res Ctr, Geneva, Switzerland

[3] Univ Hosp Geneva, Div Lab Med, Div Immunol & Allergy, Transplantat Immunol Unit, Geneva, Switzerland

[4] Univ Hosp Geneva, Div Lab Med, Div Immunol & Allergy, Swiss Natl Lab Histocompatibil, Geneva, Switzerland

[5] CHU Ste Justine, Dept Pediat, Oncol & Hematol Unit, Montreal, PQ, Canada

[6] Univ Toronto, Hosp Sick Children, Div Hematol Oncol, Canada Dept Pharm, Toronto, ON M5G 1X8, Canada

[7] CHU St Justine Res Ctr, Charles Bruneau Canc Ctr, Montreal, PQ, Canada

[8] CHU St Justine, Clin Pharmacol Unit, Montreal, PQ, Canada

来源：

PLOS ONE | 2013年 / 8卷 / 08期

关键词：

STEM-CELL TRANSPLANTATION; GRAFT FAILURE; KIDNEY-TRANSPLANTATION; MEDIATED REJECTION; DONOR; RECIPIENTS; ENGRAFTMENT; SERUM; RISK; ALLOANTIBODIES;

D O I：

10.1371/journal.pone.0072141

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1-4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I-related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti- MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes.

引用

页数：8

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