Cyclosulfamides as constraint dipeptides: The synthesis and structure of chiral substituted 1,2,5-thiadiazolidine 1,1-dioxides: Evaluation of the toxicity

被引：12

作者：

Bendjeddou, Amel ^{[1
]}

Djebbar, Houria ^{[1
]}

Berredjem, Malika ^{[1
]}

Hattab, Z'Hour ^{[1
]}

Regainia, Zine ^{[1
]}

Aouf, Nour-Eddine ^{[1
]}

机构：

[1] Badji Mokhtar Univ, Lab Chim Organ Appliquee,Fac Sci, Dept Chem, Grp Chim Bioorgan, Annaba, Algeria

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2006年 / 181卷 / 06期

关键词：

amino acids; constraints peptides; cyclic sulfamides;

D O I：

10.1080/10426500500327014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A general synthesis for the preparation of chiral N-N' substituted 1,2,5-thiadiazolidine 1,1-dioxides has been developed beginning with proteogenic amino acid, sulfuryl chloride, and dibromoethane. The selected chemistry and spectral properties of these compounds are examined. Overall, routes described are applicable to the synthesis of a variety of constrained dipeptidal sulfamides representing novel peptidomimetic scaffolds.

引用

页码：1351 / 1362

页数：12

共 26 条

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[2]

[Anonymous], 2002, ANGEW CHEM-GER EDIT, V114, P4022

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