New cytotoxic steroids from the Indian ocean sponge Axinella cf. bidderi

被引：28

作者：

Funel, C

Berrué, F

Roussakis, C

Rodriguez, RF

Amade, P ^{[1
]}

机构：

[1] Univ Nice, CNRS, UMR 6001, Chim Bioorgan Lab, F-06108 Nice 02, France

[2] Univ Nantes, Fac Pharm, ISOMER, F-44035 Nantes 01, France

[3] PharmaMar, Poligono Ind La Mina N, Colmenat Viejo, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 03期

关键词：

D O I：

10.1021/np034021t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta- ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.

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页码：491 / 494

页数：4

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