Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

被引：4861

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Vitale, Ilio ^{[4
,5
]}

Aaronson, Stuart A. ^{[6
]}

Abrams, John M. ^{[7
]}

Adam, Dieter ^{[8
]}

Agostinis, Patrizia ^{[9
]}

Alnemri, Emad S. ^{[10
]}

Altucci, Lucia ^{[11
]}

Amelio, Ivano ^{[12
]}

Andrews, David W. ^{[13
,14
,15
]}

Annicchiarico-Petruzzelli, Margherita ^{[16
]}

Antonov, Alexey V. ^{[12
]}

Arama, Eli ^{[17
]}

Baehrecke, Eric H. ^{[18
]}

Barlev, Nickolai A. ^{[19
]}

Bazan, Nicolas G. ^{[20
]}

Bernassola, Francesca ^{[21
]}

Bertrand, Mathieu J. M. ^{[22
,23
]}

Bianchi, Katiuscia ^{[24
]}

Blagosklonny, Mikhail V. ^{[25
]}

Blomgren, Klas ^{[26
,27
]}

Borner, Christoph ^{[28
,29
]}

Boya, Patricia ^{[30
]}

Brenner, Catherine ^{[31
,32
]}

Campanella, Michelangelo ^{[4
,5
,33
,34
]}

Candi, Eleonora ^{[16
,21
]}

Carmona-Gutierrez, Didac ^{[35
]}

Cecconi, Francesco ^{[4
,36
,37
]}

Chan, Francis K. -M. ^{[38
]}

Chandel, Navdeep S. ^{[39
]}

Cheng, Emily H. ^{[40
]}

Chipuk, Jerry E. ^{[6
]}

Cidlowski, John A. ^{[41
]}

Ciechanover, Aaron ^{[42
]}

Cohen, Gerald M. ^{[43
]}

Conrad, Marcus ^{[44
]}

Cubillos-Ruiz, Juan R. ^{[2
,45
]}

Czabotar, Peter E. ^{[46
,47
]}

D'Angiolella, Vincenzo ^{[48
]}

Dawson, Ted M. ^{[49
,50
,51
,52
]}

Dawson, Valina L. ^{[49
,50
,52
,53
]}

De laurenzi, Vincenzo ^{[54
]}

De Maria, Ruggero ^{[55
]}

Debatin, Klaus-Michael ^{[56
]}

DeBerardinis, Ralph J. ^{[57
]}

Deshmukh, Mohanish ^{[58
]}

Di Daniele, Nicola ^{[59
]}

Di Virgilio, Francesco ^{[60
]}

Dixit, Vishva M. ^{[61
]}

Dixon, Scott J. ^{[62
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[2] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA

[3] Paris Descartes Paris V Univ, Paris, France

[4] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[5] Regina Elena Inst Canc Res, Dept Res Adv Diagnost & Technol Innovat, Unit Cellular Networks & Mol Therapeut Targets, Rome, Italy

[6] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

[7] Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

[8] Univ Kiel, Inst Immunol, Kiel, Germany

[9] Katholieke Univ Leuven, Dept Cellular & Mol Med, Cell Death Res & Therapy CDRT Lab, Leuven, Belgium

[10] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA

[11] Univ Campania Luigi Vanvitelli, Dept Biochem Biophys & Gen Pathol, Naples, Italy

[12] Univ Leicester, MRC, Toxicol Unit, Leicester, Leics, England

[13] Sunnybrook Res Inst, Biol Sci, Toronto, ON, Canada

[14] Univ Toronto, Dept Biochem, Toronto, ON, Canada

[15] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[16] Dermopat Inst Immaculate IDI IRCCS, Biochem Lab, Rome, Italy

[17] Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel

[18] Univ Massachusetts, Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA

[19] Russian Acad Sci, Inst Cytol, St Petersburg, Russia

[20] Louisiana State Univ, Neurosci Ctr Excellence, Sch Med, New Orleans, LA USA

[21] Univ Roma Tor Vergata, Dept Expt Med & Surg, Rome, Italy

[22] VIB Ctr Inflammat Res IRC, Ghent, Belgium

[23] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[24] Queen Mary Univ London, Barts Canc Inst, Ctr Mol Oncol, London, England

[25] Roswell Pk Canc Inst, Cell Stress Biol, Buffalo, NY 14263 USA

[26] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

[27] Karolinska Univ Hosp, Dept Pediat Oncol, Stockholm, Sweden

[28] Albert Ludwigs Univ, Inst Mol Med & Cell Res, Freiburg, Germany

[29] Albert Ludwigs Univ, Fac Med, Spemann Grad Sch Biol & Med SGBM, Freiburg, Germany

[30] CSIC, Spanish Natl Res Council, Ctr Biol Investigat CIB, Dept Cellular & Mol Biol, Madrid, Spain

[31] INSERM, U1180, Chatenay Malabry, France

[32] Univ Paris Sud Paris Saclay, Orsay, France

[33] Univ London, Royal Vet Coll, Dept Comparat Biomed Sci, London, England

[34] UCL, Consortium Mitochondrial Res, London, England

[35] Karl Franzens Univ Graz, NAWI Graz, Dept Inst Mol Biosci, Graz, Austria

[36] Danish Canc Soc Res Ctr, Unit Cell Stress & Survival, Copenhagen, Denmark

[37] Bambino Gesu Childrens Hosp IRCCS, Dept Pediat Hematol & Oncol, Rome, Italy

[38] Univ Massachusetts, Med Sch, Dept Pathol, Worcester, MA 01605 USA

[39] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

[40] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[41] NIEHS, Signal Transduct Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA

[42] Technion Israel Inst Technol, TICC, Ruth & Bruce Rappaport Fac Med & Res Inst, Haifa, Israel

[43] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England

[44] German Res Ctr Environm Hlth GmbH, Helmholtz Ctr Munich, Inst Dev Genet, Munich, Germany

[45] Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY USA

[46] Walter & Eliza Hall Inst Med Res, Melbourne, Vic, Australia

[47] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia

[48] Univ Oxford, Canc Res UK & Med Res Council, Inst Radiat Oncol, Dept Oncol, Old Rd Campus Res Bldg, Oxford, England

[49] Johns Hopkins Univ, Sch Med, Neuroregenerat & Stem Cell Programs, Inst Cell Engn, Baltimore, MD USA

[50] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2018年 / 25卷 / 03期

基金：

欧洲研究理事会;

关键词：

NF-KAPPA-B; MITOCHONDRIAL PERMEABILITY TRANSITION; TUMOR-NECROSIS-FACTOR; NEUTROPHIL EXTRACELLULAR TRAPS; BCL-2; FAMILY-MEMBER; MIXED LINEAGE KINASE; NONCANONICAL INFLAMMASOME ACTIVATION; LYSOSOMAL MEMBRANE PERMEABILIZATION; GLUTATHIONE-PEROXIDASE; CYTOCHROME-C RELEASE;

D O I：

10.1038/s41418-017-0012-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

引用

页码：486 / 541

页数：56

共 1065 条

[1] Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium [J].

Aachoui, Youssef ;

Kajiwara, Yuji ;

Leaf, Irina A. ;

Mao, Dat ;

Ting, Jenny P. -Y. ;

Coers, Joern ;

Aderem, Alan ;

Buxbaum, Joseph D. ;

Miao, Edward A. .

CELL HOST & MICROBE, 2015, 18 (03) :320-332

[2] Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection [J].

Aachoui, Youssef ;

Sagulenko, Vitaliya ;

Miao, Edward A. ;

Stacey, Katryn J. .

CURRENT OPINION IN MICROBIOLOGY, 2013, 16 (03) :319-326

[3] The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone iron chelators [J].

Abeysinghe, RD ;

Roberts, PJ ;

Cooper, CE ;

MacLean, KH ;

Hider, RC ;

Porter, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (14) :7965-7972

[4] A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].

Acosta, Juan Carlos ;

Banito, Ana ;

Wuestefeld, Torsten ;

Georgilis, Athena ;

Janich, Peggy ;

Morton, Jennifer P. ;

Athineos, Dimitris ;

Kang, Tae-Won ;

Lasitschka, Felix ;

Andrulis, Mindaugas ;

Pascual, Gloria ;

Morris, Kelly J. ;

Khan, Sadaf ;

Jin, Hong ;

Dharmalingam, Gopuraja ;

Snijders, Ambrosius P. ;

Carroll, Thomas ;

Capper, David ;

Pritchard, Catrin ;

Inman, Gareth J. ;

Longerich, Thomas ;

Sansom, Owen J. ;

Aznar Benitah, Salvador ;

Zender, Lars ;

Gil, Jesus .

NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221

[5] Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy [J].

Adkins, Irena ;

Fucikova, Jitka ;

Garg, Abhishek D. ;

Agostinis, Patrizia ;

Spisek, Radek .

ONCOIMMUNOLOGY, 2014, 3 (12) :1-12

[6] Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey [J].

Aggarwal, Bharat B. ;

Gupta, Subash C. ;

Kim, Ji Hye .

BLOOD, 2012, 119 (03) :651-665

[7] GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].

Aglietti, Robin A. ;

Estevez, Alberto ;

Gupta, Aaron ;

Ramirez, Monica Gonzalez ;

Liu, Peter S. ;

Kayagaki, Nobuhiko ;

Ciferri, Claudio ;

Dixit, Vishva M. ;

Dueber, Erin C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863

[8] Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule [J].

Ahmed, Nisar ;

Yang, Ping ;

Huang, Yufei ;

Chen, Hong ;

Liu, Tengfei ;

Wang, Lingling ;

Nabi, Fazul ;

Liu, Yi ;

Chen, Qiusheng .

FRONTIERS IN PHYSIOLOGY, 2017, 8

[9] Lysosomal cell death at a glance [J].

Aits, Sonja ;

Jaattela, Marja .

JOURNAL OF CELL SCIENCE, 2013, 126 (09) :1905-1912

[10] Integrin endosomal signalling suppresses anoikis [J].

Alanko, Jonna ;

Mai, Anja ;

Jacquemet, Guillaume ;

Schauer, Kristine ;

Kaukonen, Riina ;

Saari, Markku ;

Goud, Bruno ;

Ivaska, Johanna .

NATURE CELL BIOLOGY, 2015, 17 (11) :1412-1421

← 1 2 3 4 5 6 7 8 9 10 →