Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy

被引：319

作者：

Hu, Yong ^{[1
]}

Mignani, Serge ^{[2
]}

Majoral, Jean-Pierre ^{[3
]}

Shen, Mingwu ^{[1
]}

Shi, Xiangyang ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[2] Univ Paris 05, Lab Chim & Biochim Pharmacol & Toxicol, PRES Sorbonne Paris Cite, CNRS,UMR 860, 45 Rue St Peres, F-75006 Paris, France

[3] CNRS, Lab Chim Coordinat, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France

来源：

CHEMICAL SOCIETY REVIEWS | 2018年 / 47卷 / 05期

基金：

美国国家科学基金会;

关键词：

NEPHROGENIC SYSTEMIC FIBROSIS; POLYETHYLENEIMINE-MEDIATED SYNTHESIS; MODIFIED MAGNETIC NANOPARTICLES; FACILE HYDROTHERMAL SYNTHESIS; ENTRAPPED GOLD NANOPARTICLES; ENHANCED RAMAN-SCATTERING; SIZE-CONTROLLED SYNTHESIS; CORE-SHELL NANOPARTICLES; TARGETED DRUG-DELIVERY; LARGE-SCALE SYNTHESIS;

D O I：

10.1039/c7cs00657h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aim of this original review is to highlight and analyze the most recent progress and challenges in the synthesis and surface modifications of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) for multimodal imaging and therapy applications, which represent important fields in medicine in general and cancer in particular. Thus, the oncology domain is rapidly moving to a more personalized medicine including precision imaging and theranostic approaches. Novel biocompatible Fe3O4 nanoparticulate systems have been designed for enhanced and targeted cellular uptake by surface layer coating modifications, to have improved r(2) relaxivity for sensitive magnetic resonance (MR) imaging applications, to have the ability to be used for dual mode imaging, and to be used for imaging-guided cancer therapy. In this review, we analyzed in depth the new strategies for generating biocompatible multifunctional Fe3O4 nanoplatforms for both the diagnosis and therapy of cancer.

引用

页码：1874 / 1900

页数：27

共 279 条

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