Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

被引：43
作者：
Murgia, Denise [1 ,2 ]
Mauceri, Rodolfo [2 ]
Campisi, Giuseppina [2 ]
De Caro, Viviana [1 ]
机构：
[1] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, I-90123 Palermo, Italy
[2] Univ Palermo, Dept Surg Oncol & Oral Sci, I-90127 Palermo, Italy
来源：
BIOMOLECULES | 2019年 / 9卷 / 03期
关键词：
Resveratrol; bone-regeneration; craniofacial tissue; alveolar bone loss; bone defect; resveratrol scaffold; MESENCHYMAL STEM-CELLS; GENE-EXPRESSION; OSTEOBLAST DIFFERENTIATION; SCAFFOLD; DRUG; SUPPLEMENTATION; OSTEONECROSIS; FABRICATION; ACTIVATION; DELIVERY;
D O I：
10.3390/biom9030094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts' proliferation and antagonist of osteoclasts' differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.
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页数：16
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