Preparation and characterization of poly(vinyl alcohol)-poly(vinyl pyrrolidone) blend: A biomaterial with latent medical applications

被引：22
作者：
Bernal, Andres [1 ,2 ]
Kuritka, Ivo [1 ,2 ]
Saha, Petr [1 ,2 ]
机构：
[1] Tomas Bata Univ Zlin, Fac Technol, Polymer Ctr, Zlin 76272, Czech Republic
[2] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2013年 / 127卷 / 05期
关键词：
biomaterials; mechanical properties; thermal properties; poly(vinyl alcohol); poly(vinyl pyrrolidone); THERMAL-CHARACTERISTICS; MECHANICAL-PROPERTIES; SOLID DISPERSIONS; ALCOHOL HYDROGEL; PVP HYDROGELS; CROSS-LINKING; MISCIBILITY; WATER; FILMS; POLY(N-VINYL-2-PYRROLIDONE);
D O I：
10.1002/app.37723
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Aqueous solutions of poly(vinyl alcohol) and poly(vinyl pyrrolidone) are blended and films are produced by casting method with the further intention of being used as bio-materials with latent medical application. Glutaraldehyde, 4,4'-diazido-2,2'-stilbenedisulfonic acid disodium salt tetra-hydrate are used as crosslinker agents, whereas lactic acid is the plasticizer in the blend. The obtained films are characterized by differential scanning calorimetry (DSC), mechanical properties, swelling and solubility behavior. DSC measurements show that the blends exhibit a single glass transition temperature indicating that they are miscible, even in the presence of the plasticizer and crosslinker agents. By the combination of all mentioned additives, a relevant enhancement of the swelling is observed, accompanied by a stabilization of the solubility during the tested time. Finally, mechanical properties show an appropriate performance in the studied parameters. As a consequence, the obtained films could be suitable for use as medium or long-term implants. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
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收藏
页码：3560 / 3568
页数：9
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