A review of central 5-HT receptors and their function

被引：2656

作者：

Barnes, NM ^{[1
]}

Sharp, T

机构：

[1] Univ Birmingham, Sch Med, Dept Pharmacol, Birmingham B15 2TT, W Midlands, England

[2] Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 08期

关键词：

serotonin; 5-hydroxytryptamine; 5-HT receptor function;

D O I：

10.1016/S0028-3908(99)00010-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was identified in terms of its cDNA sequence. Over this period, much effort has been directed towards understanding the function attributable to individual 5-HT receptors in the brain. This has been helped, in part, by the synthesis of a number of compounds that selectively interact with individual 5-HT receptor subtypes-although some 5-HT receptors still lack any selective ligands (e.g. 5-ht(1E), 5-ht(5A) and 5-h(t5)B receptors). The present review provides background information for each 5-HT receptor subtype and subsequently reviews in more detail the functional responses attributed to each receptor in the brain. Clearly this latter area has moved forward in recent years and this progression is likely to continue given the level of interest associated with the actions of 5-HT. This interest is stimulated by the belief that pharmacological manipulation of the central 5-HT system will have therapeutic potential. In support of which, a number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1083 / 1152

页数：70

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