Memory and Neurogenesis in Aging and Alzheimer's Disease

被引：0

作者：

Avila, Jesus ^{[1
]}

Insausti, Ricardo ^{[2
,3
]}

Del Rio, Joaquin ^{[4
]}

机构：

[1] Spanish Network Excellence Neurodegenerat Dis CIB, Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid, Spain

[2] Univ Castilla La Mancha, Human Neuroanat Lab, Sch Med, Albacete, Spain

[3] Univ Castilla La Mancha, CRIB, Albacete, Spain

[4] Univ Navarra, Div Neurosci, Ctr Appl Med Res, Spanish Network Excellence Neurodegenerat Dis CIB, Pamplona 31008, Spain

来源：

AGING AND DISEASE | 2010年 / 1卷 / 01期

关键词：

GSK3; dentate gyrus; Familial Alzheimer's disease;

D O I：

暂无

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A possible link between a deficient neurogenesis at the dentate gyrus, and the loss of memory found in Alzheimer's disease patients is discussed. First is indicated that Alzheimer disease is a memory disorder. Since adult neurogenesis at the dentate gyrus plays a role in declarative memory, a brief comment on the structure and function of dentate gyrus has been included. At molecular level, we have discussed the function of the enzyme GSK3 on the development of neurogenesis at the subgranular zone of the dentate gyrus. Finally, we have indicated that in Alzheimer disease there is an increase in GSK3 activity. This increase could impair the neurogenesis process and it could result in the memory deficit found in Alzheimer patients.

引用

页码：30 / 36

页数：7

共 59 条

[1] Adult neurogenesis: From precursors to network and physiology [J].