H2S as a potential defense against COVID-19?

被引:43
作者
Yang, Guangdong [1 ,2 ]
机构
[1] Laurentian Univ, Cardiovasc & Metab Res Unit, Sudbury, ON, Canada
[2] Laurentian Univ, Dept Chem & Biochem, Sudbury, ON, Canada
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2020年 / 319卷 / 02期
基金
加拿大自然科学与工程研究理事会;
关键词
ACE2; COVID-19; H2S; SARS-CoV-2; TMPRSS2; CONVERTING ENZYME 2; ACUTE LUNG INJURY; RESPIRATORY SYNCYTIAL VIRUS; HYDROGEN-SULFIDE PROTECTS; INFLAMMATION; ACTIVATION; ANGIOTENSIN-CONVERTING-ENZYME-2; GASOTRANSMITTER; METABOLISM; DISCOVERY;
D O I
10.1152/ajpcell.00187.2020
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). There is currently no vaccine available and also no effective drug for the treatment of COVID-19. Hydrogen sulfide (H2S) as a novel gasotransmitter has been shown to protect against lung damage via its anti-inflammation, antioxidative stress, antiviral, prosurvival, and antiaging effects. In light of the research advances on H2S signaling in biology and medicine, this review proposed H2S as a potential defense against COVID-19. It is suggested that H2S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development. Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19.
引用
收藏
页码:C244 / C249
页数:6
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