机构:
Laurentian Univ, Cardiovasc & Metab Res Unit, Sudbury, ON, Canada
Laurentian Univ, Dept Chem & Biochem, Sudbury, ON, CanadaLaurentian Univ, Cardiovasc & Metab Res Unit, Sudbury, ON, Canada
Yang, Guangdong
[1
,2
]
机构:
[1] Laurentian Univ, Cardiovasc & Metab Res Unit, Sudbury, ON, Canada
[2] Laurentian Univ, Dept Chem & Biochem, Sudbury, ON, Canada
来源:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
|
2020年
/
319卷
/
02期
The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). There is currently no vaccine available and also no effective drug for the treatment of COVID-19. Hydrogen sulfide (H2S) as a novel gasotransmitter has been shown to protect against lung damage via its anti-inflammation, antioxidative stress, antiviral, prosurvival, and antiaging effects. In light of the research advances on H2S signaling in biology and medicine, this review proposed H2S as a potential defense against COVID-19. It is suggested that H2S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development. Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19.
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Tang, Bo
;
Ma, Lan
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Ma, Lan
;
Yao, Xiaoyi
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Yao, Xiaoyi
;
Tan, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Tan, Gang
;
Han, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Han, Peng
;
Yu, Tianchi
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Yu, Tianchi
;
Liu, Bing
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Liu, Bing
;
Sun, Xueying
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Peking Univ, Dept Pulm, Crit Care Med, Peoples Hosp, Beijing, Peoples R ChinaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Wang, Peipei
;
Wu, Lingyun
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Sci North Res Inst, Sudbury, ON, Canada
Laurentian Univ, Sch Human Kinet, Sudbury, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Wu, Lingyun
;
Ju, Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Sch Kinesiol, Thunder Bay, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Ju, Yongjun
;
Fu, Ming
论文数: 0引用数: 0
h-index: 0
机构:
Laurentian Univ, Sch Human Kinet, Sudbury, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Fu, Ming
;
Shuang, Tian
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Shuang, Tian
;
Qian, Zhongming
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Sch Pharm, Lab Neuropharmacol, Shanghai, Peoples R ChinaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Qian, Zhongming
;
Wang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
机构:
Lakehead Univ, Off Vice President Res Econ Dev & Innovat, Dept Biol, Thunder Bay, ON P7B 5E1, CanadaLakehead Univ, Off Vice President Res Econ Dev & Innovat, Dept Biol, Thunder Bay, ON P7B 5E1, Canada
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Xu, Dun-quan
;
Gao, Cao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Gao, Cao
;
Niu, Wen
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Niu, Wen
;
Li, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Mil Gen Hosp, Med Examinat Ctr, Beijing 100007, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Li, Yan
;
Wang, Yan-xia
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Wang, Yan-xia
;
Gao, Chang-jun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Gao, Chang-jun
;
Ding, Qian
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Ding, Qian
;
Yao, Li-nong
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Yao, Li-nong
;
Chai, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Chai, Wei
;
Li, Zhi-chao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Tang, Bo
;
Ma, Lan
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Ma, Lan
;
Yao, Xiaoyi
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Yao, Xiaoyi
;
Tan, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Tan, Gang
;
Han, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Han, Peng
;
Yu, Tianchi
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Yu, Tianchi
;
Liu, Bing
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
Liu, Bing
;
Sun, Xueying
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, Harbin 150001, Peoples R China
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Peking Univ, Dept Pulm, Crit Care Med, Peoples Hosp, Beijing, Peoples R ChinaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Wang, Peipei
;
Wu, Lingyun
论文数: 0引用数: 0
h-index: 0
机构:
Hlth Sci North Res Inst, Sudbury, ON, Canada
Laurentian Univ, Sch Human Kinet, Sudbury, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Wu, Lingyun
;
Ju, Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Sch Kinesiol, Thunder Bay, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Ju, Yongjun
;
Fu, Ming
论文数: 0引用数: 0
h-index: 0
机构:
Laurentian Univ, Sch Human Kinet, Sudbury, ON, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Fu, Ming
;
Shuang, Tian
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Shuang, Tian
;
Qian, Zhongming
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Sch Pharm, Lab Neuropharmacol, Shanghai, Peoples R ChinaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Qian, Zhongming
;
Wang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Lakehead Univ, Dept Biol, Thunder Bay, ON, Canada
Laurentian Univ, Cardiovasc & Metab Res Unit, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, CanadaLakehead Univ, Dept Biol, Thunder Bay, ON, Canada
机构:
Lakehead Univ, Off Vice President Res Econ Dev & Innovat, Dept Biol, Thunder Bay, ON P7B 5E1, CanadaLakehead Univ, Off Vice President Res Econ Dev & Innovat, Dept Biol, Thunder Bay, ON P7B 5E1, Canada
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Xu, Dun-quan
;
Gao, Cao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Gao, Cao
;
Niu, Wen
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Niu, Wen
;
Li, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Mil Gen Hosp, Med Examinat Ctr, Beijing 100007, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Li, Yan
;
Wang, Yan-xia
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Wang, Yan-xia
;
Gao, Chang-jun
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Gao, Chang-jun
;
Ding, Qian
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Ding, Qian
;
Yao, Li-nong
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Yao, Li-nong
;
Chai, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Anesthesiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China
Chai, Wei
;
Li, Zhi-chao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Dept Pathol & Pathophysiol, Xian 710038, Peoples R China