The curious case of the tumour virus: 50 years of Burkitt's lymphoma

被引：199

作者：

Thorley-Lawson, David A. ^{[1
]}

Allday, Martin J. ^{[2
]}

机构：

[1] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Virol, London W2 1PG, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nrmicro2015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation.

引用

页码：913 / 924

页数：12

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