Venlafaxine and Neuropathic Pain

被引：23

作者：

Cegielska-Perun, Krystyna ^{[1
]}

Bujalska-Zadrozny, Magdalena ^{[1
]}

Tatarkiewicz, Jan ^{[1
]}

Gasinska, Emilia ^{[1
]}

Makulska-Nowak, Helena Elzbieta ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Pharmacodynam, PL-00927 Warsaw 64, Poland

来源：

PHARMACOLOGY | 2013年 / 91卷 / 1-2期

关键词：

Diabetes; Streptozotocin-induced hyperalgesia; Venlafaxine; Naloxone; Yohimbine; p-Chloroamphetamine; MONOAMINE TRANSPORTERS; INHIBITORS; MODELS; RATS; HYPERALGESIA; NOCICEPTION; MECHANISMS; SEROTONIN; EFFICACY;

D O I：

10.1159/000345035

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The possible mechanisms involved in the antinociceptive effect of venlafaxine (VFX), a selective serotonin and noradrenaline reuptake inhibitor, after a single administration and chronic treatment were investigated in a diabetic neuropathic pain (DNP) model. VFX produced a significant antihyperalgesic effect after a single and repeated administration. This effect was reversed by pretreatment with yohimbine (a relatively selective alpha(2)-adrenergic antagonist) and p-chloroamphetamine (a neurotoxin which destroys serotonergic neurons). Conversely, naloxone (a nonselective opioid antagonist) did not reverse the effect of VEX in a DNP model. It is concluded that both noradrenergic and serotonergic mechanisms participate in the antinociceptive effect of VFX in the DNP model. However, the noradrenergic mechanism probably plays a more important role. Copyright (c) 2012 S. Karger AG, Basel

引用

页码：69 / 76

页数：8

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