Geographical Distribution of Myasthenia Gravis in Northern Europe - Results from a Population-Based Study from Two Countries

被引：34

作者：

Boldingh, Marion I. ^{[1
,2
]}

Maniaol, Angelina H. ^{[1
,2
]}

Brunborg, Cathrine ^{[1
,2
,3
]}

Dekker, Luuk ^{[5
]}

Heldal, Anne T. ^{[4
]}

Lipka, A. F. ^{[5
]}

Popperud, Trine H. ^{[1
,2
]}

Niks, Erik H. ^{[5
]}

Verschuuren, J. J. G. M. ^{[5
]}

Tallaksen, Chantal M. E. ^{[1
,2
,6
]}

机构：

[1] Oslo Univ Hosp, Dept Neurol, Ulleval, Norway

[2] Univ Oslo, Rikshosp, N-0027 Oslo, Norway

[3] Oslo Univ Hosp, Res Support Serv, Oslo Ctr Biostat & Epidemiol, NO-0424 Oslo, Norway

[4] Univ Bergen, Dept Clin Med, Bergen, Norway

[5] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands

[6] Univ Oslo, Inst Clin Med, Oslo, Norway

来源：

NEUROEPIDEMIOLOGY | 2015年 / 44卷 / 04期

关键词：

Myasthenia gravis; prevalence; Muscle specific tyrosine kinase antibody; Acetylcholine receptor antibody; Late-onset myasthenia gravis; Phenotype; MULTIPLE-SCLEROSIS; ONSET MYASTHENIA; EPIDEMIOLOGY; ANTIBODY; ASSOCIATION; PREVALENCE; FREQUENCY; BELGRADE; PROVINCE; DENMARK;

D O I：

10.1159/000431036

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives: To compare the prevalence of myasthenia gravis (MG) subgroups based on immunological markers and clinical presentation in two geographically complete MG populations in northern Europe. Methods:This cross-sectional study included all living MG patients in Norway and a regional cohort from the Netherlands. Patients were identified using their hospital registration codes. Medical charts of subjects >16 years were reviewed. Inclusion criteria were clinical MG, a positive antibody test for acetylcholine receptor (AChR MG) or muscle-specific kinase (MuSK MG), or if seronegative MG, confirmed by an electrophysiological test. Results: 1,205 MG patients (534 Norwegians and 671 Dutch) fulfilled the criteria, giving a higher point prevalence in the Netherlands (167/million, 95% CI 155-180) than in Norway (138/million, 95% CI 126-150). In particular, rates of AChR MG (143 vs. 111/million), MuSK MG (6.5 vs. 0.5/million), and ocular phenotype (62 vs. 24/million) were higher in the Netherlands. Conclusion: Novel findings are an AChR MG geographical north south gradient and a 2.6-fold more ocular MG patients in the Netherlands than in Norway. The MuSK MG latitudinal gradient supports the notion of a north south gradient in Europe, with a higher prevalence in the south. The variation is probably explained by genetic differences between the populations, in addition to environmental interactions. (C) 2015 S. Karger AG, Basel

引用

页码：221 / 231

页数：11

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