First relationships between detoxication properties of some 1,2-dithiole-3-thiones and their log P

被引：11

作者：

Burgot, G ^{[1
]}

Bona, M ^{[1
]}

Christen, MO ^{[1
]}

Burgot, JL ^{[1
]}

机构：

[1] SOLVAY PHARMA,LAB THERAPEUT MODERNE,SURESNES,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 129卷 / 1-2期

关键词：

1,2-dithiole-3-thiones; electrophile detoxication; water/n-octanol log P; quantitative structure-activity relationships;

D O I：

10.1016/0378-5173(95)04260-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

First quantitative structure-activity relationships (QSAR) between electrophile detoxication properties of 1,2-dithiole-3-thiones and their log P values were checked. A very significant linear property was found with some disubstituted derivatives. In all cases,it was found that the less lipophilic dithiolethiones were the most active.

引用

页码：295 / 299

页数：5

共 5 条

[1] A GENERAL-SYNTHESIS OF NEW DITHIOLETHIONE DERIVATIVES - 5-(1-HYDROXYIMINO ALKYL)-1,2-DITHIOLE-3-THIONES AND 5-ACYL-1,2-DITHIOLE-3-THIONES [J].