Physicochemical properties of an anticonvulsant drug sodium valproate in aqueous and in mixed aqueous solutions at different temperatures

被引:48
作者
Mondal, Sudip [1 ,2 ]
Dhondge, Sudhakar S. [1 ]
Paliwal, Lalitmohan J. [2 ]
Tangde, Vijay M. [2 ]
Jengathe, Santosh P. [1 ,2 ]
机构
[1] SK Porwal Coll, PG Dept Chem, Kamptee 441001, India
[2] RTM Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India
关键词
Density; Viscosity; Sodium valproate; Apparent molar volume of transfer; Energy of activation of viscous flow; Co-sphere overlap model; PARTIAL MOLAR VOLUMES; BETAINE HYDROCHLORIDE DRUG; SOLVATION BEHAVIOR; ORGANIC-COMPOUNDS; AMINO-ACIDS; VISCOSITY; WATER; COMPRESSIBILITY; CHLORIDE; NACL;
D O I
10.1016/j.jct.2015.06.025
中图分类号
O414.1 [热力学];
学科分类号
摘要
The study of fundamental thermodynamic properties of aqueous solutions is very important to derive the information about (solute + solvent) and (solute + solute) interactions. Sodium valproate is a very important drug used for treatment of epilepsy, anorexia nervosa, panic attack, anxiety disorder etc. In this communication we report apparent molar volume of solute (V-phi), limiting apparent molar volume of solute (V-phi(0)), limiting apparent molar expansivity of solute (E-phi(0)), thermal expansion coefficient (alpha*), double derivative of limiting apparent molar volume (partial derivative V-2(phi)0/partial derivative T-2), Jones-Dole equation viscosity A, B and D coefficients, temperature derivative of B coefficient i.e., (dB/dT) and hydration number (n(H)) for aqueous solutions of sodium valproate and solutions of sodium valproate in aqueous solutions of sodium chloride and dextrose. The above parameters have been obtained from measured values of densities (rho) and absolute viscosities (eta) for aqueous binary mixtures of sodium valproate and for the ternary mixtures of sodium valproate in 0.06 mol . kg(-1) aqueous solutions of sodium chloride and in 0.06 mol . kg(-1) aqueous solutions of dextrose in the concentration range (0.01 to 0.1) mol . kg (1) as a function of temperature at T/K = (288.15, 298.15 and 308.15) and at atmospheric pressure. The values of limiting apparent molar volume of transfer (Delta V-tr(phi)0), and viscosity B-coefficient of transfer (Delta B-tr) have also been calculated. The transition state theory was used to obtain the Gibbs free energy of activation of viscous flow per mole of solvent (Delta mu(0#)(1)) and per mole of solute (Delta mu(0#)(2)). The related activation parameters like Delta S-2(0#) and Delta H-2(0#) have also been derived. Co-sphere overlap model has been used to understand the results in terms of molecular interactions (hydrophilic, hydrophobic and ionic interactions). The results have been interpreted in terms of complex drug - water - co-solute (NaCl and Dextrose) interactions. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:147 / 157
页数:11
相关论文
共 50 条
[21]   Volumetric and Viscometric Analyses for L-Glutamic Acid in NaCl Aqueous Solutions at Different Temperatures [J].
Iulian, Olga ;
Stefaniu, Amalia .
JOURNAL OF SOLUTION CHEMISTRY, 2013, 42 (03) :676-689
[22]   Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ-amino butyric acid in aqueous medium at T = (288.15-318.15) K and at p=1 x 105 Pa [J].
Beri, Aashima ;
Kant, Rishi ;
Banipal, Tarlok Singh .
VIETNAM JOURNAL OF CHEMISTRY, 2024, 62 (04) :517-526
[23]   Solute-solute and solute-solvent interactions of drug sodium salicylate in aqueous-glucose/sucrose solutions at temperatures from 293.15 to 318.15 K: A physicochemical study [J].
Ankita ;
Nain, Anil Kumar .
JOURNAL OF MOLECULAR LIQUIDS, 2020, 298
[24]   Volumetric, viscometric, and acoustic behaviour of diglycine in aqueous saccharide solutions at different temperatures [J].
Pal, Amalendu ;
Chauhan, Nalin .
JOURNAL OF MOLECULAR LIQUIDS, 2009, 149 (1-2) :29-36
[25]   Physicochemical Properties of Aqueous Hydroxylamine Sulfate and Aqueous (Hydroxylamine Sulfate plus Ammonium Sulfate) Solutions at Different Temperatures [J].
Fang, Sheng ;
Zhang, Jian-Guo ;
Liu, Jian-Qing ;
Liu, Ming ;
Luo, Sheng ;
He, Chao-Hong .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2009, 54 (07) :2028-2032
[26]   Volumetric, acoustical and viscometric behavior of glycine and DL-alanine in aqueous furosemide solutions at different temperatures [J].
Chauhan, Suvarcha ;
Pathania, Lalita ;
Sharma, Kundan ;
Kumar, G. .
JOURNAL OF MOLECULAR LIQUIDS, 2015, 212 :656-664
[27]   Exploring molecular interactions of sucrose in aqueous potassium clavulanate solutions at different temperatures: volumetric and acoustic approaches [J].
Rathi, Meenakshi .
MULTISCALE AND MULTIDISCIPLINARY MODELING EXPERIMENTS AND DESIGN, 2024, 7 (03) :2717-2730
[28]   Investigation of the effect of temperature on aggregation behaviour and thermodynamic properties of Ornithine monohydrochloride in aqueous and aqueous dextrose and urea solutions [J].
Sheikh, Nikhat G. ;
Tangde, Vijay M. ;
Dhondge, Sudhakar S. ;
Dhondge, Alka S. ;
Khaty, Niraj T. .
JOURNAL OF CHEMICAL THERMODYNAMICS, 2020, 151
[29]   Interaction of Some Amino Acids with Sodium Dodecyl Sulphate in Aqueous Solution at Different Temperatures [J].
Ali, Anwar ;
Itoo, Firdoos Ahmad ;
Ansari, Nizamul Haque .
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION A-A JOURNAL OF PHYSICAL SCIENCES, 2011, 66 (05) :345-352
[30]   Density, viscosity and ultrasonic velocity studies of aqueous solutions of sodium acetate at different temperatures [J].
Kharat, S. J. .
JOURNAL OF MOLECULAR LIQUIDS, 2008, 140 (1-3) :10-14