Asymmetric cyclopropanation reaction under phase-transfer catalyzed conditions

被引：94

作者：

Arai, S ^{[1
]}

Nakayama, K

Ishida, T

Shioiri, T

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691041, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 22期

关键词：

asymmetric reactions; catalysts; cyclopropanes; phase transfer;

D O I：

10.1016/S0040-4039(99)00679-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric cyclopropanation reaction was developed using chiral quaternary ammonium salts as the phase-transfer catalyst (PTC). The reaction smoothly proceeded to give the desired bicyclic compounds with complete stereocontrol in the presence of a catalytic amount of chiral quaternary salts as the PTC, which are derived from readily available chiral amines, with up to 83% ee under mild reaction conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4215 / 4218

页数：4

共 11 条

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