Homing and engraftment of bone marrow cells derived from different donors in a murine model of sensitization

被引：4
作者：
Xu, Lu-Hong [1 ,2 ]
Fang, Jian-Pei [1 ,2 ]
Xu, Hong-Gui [1 ,2 ]
Weng, Wen-Jun [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Dept Pediat, Sun Yat Sen Mem Hosp, Guangzhou 510120, Peoples R China
[2] Sun Yat Sen Univ, Guangdong Higher Educ Inst, Key Lab Malignant Tumor Gene Regulat & Target The, Guangzhou 510120, Peoples R China
来源：
HEMATOLOGY | 2012年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Homing; Engraftment; Bone marrow cells; Sensitization; APLASTIC-ANEMIA; T-CELLS; TRANSPLANTATION; THALASSEMIA; BLOOD; TRANSFUSION; RECIPIENTS; ALLOIMMUNIZATION; DIAGNOSIS; CHILDREN;
D O I：
10.1179/102453312X13376952196539
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sensitized recipients are at a high risk of graft rejection in hematopoietic stem cell transplantation. To explore the trace of donor cells, we tried to explore homing and engraftment of bone marrow cells (BMCs) derived from different donors in a murine model of sensitization. Sensitized BALB/c mice were used as transplanted recipients, which received BMCs derived from C57BL/6 or BALB/c donors after lethal irradiation. The homing study showed that the donor cells decreased along with time in recipients of the C57BL/6 donor group, but the donor cells increased along with time in recipients of the BALB/c donor group. For the engraftment assay, all the sensitized recipients transplanted with BMCs derived from C57BL/6 donors died after lethal irradiation. In contrast, all the recipients transplanted with BMCs derived from BALB/c donors got long-term survival. Our results suggest that it is crucial to have human leukocyte antigen identical donors for sensitized recipients during hematopoietic stem cell transplantation.
引用
收藏
页码：215 / 219
页数：5
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