Voltage-activated sodium currents in acutely isolated mouse vestibular ganglion neurones

被引：27

作者：

Chabbert, C ^{[1
]}

Chambard, JM ^{[1
]}

Valmier, J ^{[1
]}

Sans, A ^{[1
]}

Desmadryl, G ^{[1
]}

机构：

[1] INST BIOL,CNRS,UPR 9008,INSERM,U249,F-34060 MONTPELLIER,FRANCE

来源：

NEUROREPORT | 1997年 / 8卷 / 05期

关键词：

mouse; sodium current; vestibular ganglion neurones; voltage clamp;

D O I：

10.1097/00001756-199703240-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

VOLTAGE-ACTIVATED sodium currents (I-Na) in vestibular ganglion neurones acutely isolated from postnatal mice were investigated using the whole-cell configuration of the patch-clamp technique. Under recording conditions designed to allow the complete isolation of I-Na depolarizations from a holding potential of -80 mV revealed a fast inactivating inward current which was activated around -60 mV and exhibited maximum peak current around -30 mV. This current was eliminated when the cells were perifused with a Na+-free solution and almost totally blocked by application of 100 nM tetrodotoxin (TTX). These properties identify this inward current as TTX-sensitive I-Na. The half-maximum activation potential of I-Na was -46 mV and its half-maximum inactivation potential was -69 mV. This is the first report of voltage-activated sodium currents in vestibular primary neurones.

引用

页码：1253 / 1256

页数：4

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