Changes in macrolide resistance among respiratory pathogens after decreased erythromycin consumption in Taiwan

被引：23
作者：
Hsueh, PR
Shyr, JM
Wu, JJ
机构：
[1] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan
[2] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
[3] Taichung Vet Gen Hosp, Dept Clin Pathol, Taichung, Taiwan
[4] Natl Cheng Kung Univ, Sch Med Technol, Tainan 70101, Taiwan
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 03期
关键词：
antibiotic consumption; Haemophilus influenzae; macrolides; resistance; Streptococcus spp;
D O I：
10.1111/j.1469-0691.2005.01348.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Measures to alleviate the growing problem of macrolide resistance in Taiwan resulted in a decrease in macrolide consumption, from 0.629 defined daily doses/1000 inhabitants per day (DIDs) in 1999 to 0.301 DIDs in 2003 (a reduction of 52%). A linear relationship was observed between the decline in erythromycin consumption and the decline in erythromycin resistance in Streptococcus pyogenes (46% in 1999 vs. 17% in 2003; p < 0.001) and azithromycin resistance in Haemophilus influenzae (31% in 2000 vs. 0% in 2003; p < 0.001). However, the rate of erythromycin resistance in Streptococcus pneumoniae showed a continued increase, from 80.2% in 1999 to 92% in 2003.
引用
收藏
页码：296 / 298
页数：4
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