Diffuse Midline Glioma With Osseous Metastases at Diagnosis: A Case Report

被引：7

作者：

Bhatt, Neel S. ^{[1
]}

Houser, Kerri ^{[3
]}

Belongia, Meghan ^{[4
]}

Ellison, David W. ^{[2
]}

Foy, Andrew ^{[5
]}

Jarzembowski, Jason ^{[6
]}

Kelly, Teresa ^{[7
]}

Maheshwari, Mohit ^{[7
]}

Suchi, Mariko ^{[6
]}

Knipstein, Jeffrey ^{[4
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] Med Coll Wisconsin, Dept Pediat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Dept Pediat, Div Hematol Oncol Blood & Marrow Transplant, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[5] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA

[6] Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA

[7] Med Coll Wisconsin, Dept Radiol, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 07期

关键词：

high-grade glioma; extaneural; metastasis; PEDIATRIC HIGH-GRADE; CENTRAL-NERVOUS-SYSTEM; GLIOBLASTOMA-MULTIFORME; TUMORS; REVEALS; BRAIN;

D O I：

10.1097/MPH.0000000000001598

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extraneural metastasis is extremely rare in pediatric patients with high-grade glioma and carries a grim prognosis. Detection of metastases at initial presentation is even rarer. A 15-year-old adolescent girl presented with paraplegia, urinary retention, and a constellation of systemic symptoms. Imaging showed a fourth ventricular lesion, innumerable intradural lesions, leptomeningeal seeding throughout the neuraxis, and numerous osteoblastic lesions involving the spine, ribs, sternum, pelvis, humerus, and femurs. Pathology confirmed metastatic diffuse midline glioma, H3K27M-mutant. Our patient died 2 weeks after initial presentation. Further work is needed to develop effective treatment strategies for these high-risk patients.

引用

页码：E673 / E676

页数：4

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