Network analysis of GWAS data

被引：66

作者：

Leiserson, Mark D. M. ^{[1
,2
]}

Eldridge, Jonathan V. ^{[1
,2
]}

Ramachandran, Sohini ^{[2
,3
]}

Raphael, Benjamin J. ^{[1
,2
]}

机构：

[1] Brown Univ, Dept Comp Sci, Providence, RI 02912 USA

[2] Brown Univ, Ctr Computat Mol Biol, Providence, RI 02912 USA

[3] Brown Univ, Dept Ecol & Evolutionary Biol, Providence, RI 02912 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 06期

基金：

美国国家科学基金会;

关键词：

GENOME-WIDE ASSOCIATION; CANDIDATE DISEASE GENES; PROTEIN-INTERACTION NETWORK; MISSING HERITABILITY; TOPOLOGICAL SIMILARITY; INTERACTOME; PATHWAYS; PRIORITIZATION; VARIANTS; PHENOME;

D O I：

10.1016/j.gde.2013.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genome-wide association studies (GWAS) identify genetic variants that distinguish a control population from a population with a specific trait. Two challenges in GWAS are: (1) identification of the causal variant within a longer haplotype that is associated with the trait; (2) identification of causal variants for polygenic traits that are caused by variants in multiple genes within a pathway. We review recent methods that use information in protein-protein and protein-DNA interaction networks to address these two challenges.

引用

页码：602 / 610

页数：9

共 56 条

[51] Network-based global inference of human disease genes [J].

Wu, Xuebing ;

Jiang, Rui ;

Zhang, Michael Q. ;

Li, Shao .

MOLECULAR SYSTEMS BIOLOGY, 2008, 4 (1)

[52] Align human interactome with phenome to identify causative genes and networks underlying disease families [J].

Wu, Xuebing ;

Liu, Qifang ;

Jiang, Rui .

BIOINFORMATICS, 2009, 25 (01) :98-104

[53] Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity [J].

Yeger-Lotem, Esti ;

Riva, Laura ;

Su, Linhui Julie ;

Gitler, Aaron D. ;

Cashikar, Anil G. ;

King, Oliver D. ;

Auluck, Pavan K. ;

Geddie, Melissa L. ;

Valastyan, Julie S. ;

Karger, David R. ;

Lindquist, Susan ;

Fraenkel, Ernest .

NATURE GENETICS, 2009, 41 (03) :316-323

[54]

Yu HY, 2011, NAT METHODS, V8, P478, DOI [10.1038/NMETH.1597, 10.1038/nmeth.1597]

[55] Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles [J].

Zhu, Jie ;

Qin, Yufang ;

Liu, Taigang ;

Wang, Jun ;

Zheng, Xiaoqi .

BMC BIOINFORMATICS, 2013, 14

[56] The mystery of missing heritability: Genetic interactions create phantom heritability [J].

Zuk, Or ;

Hechter, Eliana ;

Sunyaev, Shamil R. ;

Lander, Eric S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (04) :1193-1198

← 1 2 3 4 5 6 →