Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9-Specified Gene Expression Signature

被引：0
|
作者：
Sachs, Zohar [1 ,2 ]
Hanh Nguyen [3 ]
Hassan, Nurul Azyan Mohd
Rathe, Susan K. [4 ]
Sachs, Karen
Diaz-Flores, Ernesto [5 ]
Bendall, Sean C.
Diers, Miechaleen D. [4 ]
Nolan, Garry P. [6 ]
Shannon, Kevin M. [7 ]
Largaespada, David A.
机构：
[1] Univ Minnesota, Div Hem Onc, Minneapolis, MN USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Div Hematol Oncol, Minneapolis, MN USA
[4] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA
[5] Univ Calif San Francisco, Div Oncol, San Francisco, CA 94143 USA
[6] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA
[7] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA
来源：
BLOOD | 2012年 / 120卷 / 21期
关键词：
D O I：
10.1182/blood.V120.21.5116.5116
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
5116
引用
收藏
页数：1
相关论文
共 17 条
  • [1] Activated NRAS mediates self-renewal capacity in AML
    Sachs, Zohar
    Rathe, Susan K.
    Diaz-Flores, Ernesto
    Diers, Miechaleen D.
    Shannon, Kevin
    Largaespada, David A.
    CANCER RESEARCH, 2012, 72
  • [2] Differential expression of Mll-AF9 up-regulated genes correlates with enhanced self-renewal of hematopoietic progenitors.
    Kumar, Ashish R.
    Hudson, Wendy A.
    Chen, Weili
    Staggs, Rodney A.
    Lamblin, Anne-Francoise
    Kersey, John H.
    BLOOD, 2006, 108 (11) : 220A - 220A
  • [3] Benzene-induced hematotoxicity enhances the self-renewal ability of HSPCs in Mll-Af9 mice
    Zhou, Jin
    Sui, Pinpin
    Zhao, Jianxin
    Cheng, Xiurong
    Yu, Tao
    Cui, Shiwei
    Song, Xiangrong
    Xing, Caihong
    TOXICOLOGY, 2025, 511
  • [4] The Mll-AF9 knock-in fusion gene results in reprogramming and enhanced self-renewal of hematopoietic progenitors, especially in the HSC and CLP populations.
    Chen, Weili
    Kumar, Ashish R.
    Hudson, Wendy A.
    Li, Quanzhi
    Kersey, John H.
    BLOOD, 2006, 108 (11) : 413A - 413A
  • [5] Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT
    Gessner, A.
    Thomas, M.
    Castro, P. Garrido
    Buechler, L.
    Scholz, A.
    Bruemmendorf, T. H.
    Soria, N. Martinez
    Vormoor, J.
    Greil, J.
    Heidenreich, O.
    LEUKEMIA, 2010, 24 (10) : 1751 - 1759
  • [6] Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT
    A Gessner
    M Thomas
    P Garrido Castro
    L Büchler
    A Scholz
    T H Brümmendorf
    N Martinez Soria
    J Vormoor
    J Greil
    O Heidenreich
    Leukemia, 2010, 24 : 1751 - 1759
  • [7] KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia
    Lewis, Andrew
    Park, Chun Shik
    Puppi, Monica
    Lacorazza, H. Daniel
    BLOOD, 2019, 134
  • [8] MLL-AF9-and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
    Zhu, Nan
    Chen, Mo
    Eng, Rowena
    DeJong, Joshua
    Sinha, Amit U.
    Rahnamay, Noushin F.
    Roche, Richard
    Al-Shahrour, Fatima
    Minehart, Janna C.
    Chen, Chun-Wei
    Deshpande, Aniruddha J.
    Xu, Haiming
    Chu, S. Haihua
    Ebert, Benjamin L.
    Roeder, Robert G.
    Armstrong, Scott A.
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (03): : 997 - 1011
  • [9] Identification of a Gene Expression Signature Characterizing Clonal Fitness and Dominance in Vivo in a Murine Model of MLL-AF9 Leukemia
    Mercier, Francois
    Shi, Jiantao
    Sykes, David
    Kfoury, Youmna Sami
    Yusuf, Rushdia Z.
    Miller, Elizabeth
    Vasic, Radovan
    Zhu, Alex
    Michor, Franziska
    Hide, Winston
    Scadden, David T.
    BLOOD, 2014, 124 (21)
  • [10] L-myc Gene Expression in Canine Fetal Fibroblasts Promotes Self-Renewal Capacity but Not Tumor Formation
    Kim, So Hee
    Kim, Bokyung
    Kim, Jung Hak
    Kim, Dong-Hoon
    Lee, Seung Hoon
    Lee, Dong-Seok
    Lee, Hong J.
    CELLS, 2021, 10 (08)
12