Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension

被引：16

作者：

Nakayama, T

Soma, M

Rahmutula, D

Tobe, H

Sato, M

Uwabo, J

Aoi, N

Kosuge, K

Kunimoto, M

Kanmatsuse, K

Kokubun, S

机构：

[1] Adv Med Res Ctr, Div Receptor Biol, Itabashi Ku, Tokyo 1738610, Japan

[2] Nihon Univ, Sch Med, Dept Internal Med 2, Tokyo 173, Japan

来源：

HYPERTENSION RESEARCH | 2002年 / 25卷 / 01期

关键词：

prostacyclin synthase gene; promoter; essential hypertension; single nucleotide polymorphism; association study;

D O I：

10.1291/hypres.25.65

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5-flanking region. We performed an association study using the SNP in 200 patients and 200 controls. The allele frequency distribution in the two groups was not significantly different. Thus, this SNP in the PGIS gene is not associated with EH.

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收藏

页码：65 / 68

页数：4

相关论文

共 17 条

[1] THE PROSTACYCLIN-THROMBOXANE-A2 BALANCE - PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS [J].

BUNTING, S ;

MONCADA, S ;

VANE, JR .

BRITISH MEDICAL BULLETIN, 1983, 39 (03) :271-276

[2] Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1) [J].

Chevalier, D ;

Cauffiez, C ;

Bernard, C ;

Lo-Guidice, JM ;

Allorge, D ;

Fazio, F ;

Ferrari, N ;

Libersa, C ;

Lhermitte, M ;

D'Halluin, JC ;

Broly, F .

HUMAN GENETICS, 2001, 108 (02) :148-155

[3]

CREED L, 1986, SEMIN NEUROL, V6, P293

[4] Human prostacyclin synthase gene and hypertension - The Suita Study [J].

Iwai, N ;

Katsuya, T ;

Ishikawa, K ;

Mannami, T ;

Ogata, J ;

Higaki, J ;

Ogihara, T ;

Tanabe, T ;

Baba, S .

CIRCULATION, 1999, 100 (22) :2231-2236

[5] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665

[6] Nonsense mutation of prostacyclin synthase gene in a family [J].

Nakayama, T ;

Soma, M ;

Rahmutula, D ;

Izumi, Y ;

Kanmatsuse, K .

LANCET, 1997, 349 (9069) :1887-1888

[7] Organization of the human prostacyclin synthase gene [J].

Nakayama, T ;

Soma, M ;

Izumi, Y ;

Kanmatsuse, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (03) :803-806

[8] Association of 5′ upstream promoter region of prostacyclin synthase gene variant with cerebral infarction [J].

Nakayama, T ;

Soma, M ;

Rehemudula, D ;

Takahashi, Y ;

Tobe, H ;

Satoh, M ;

Uwabo, J ;

Kunimoto, M ;

Kanmatsuse, K .

AMERICAN JOURNAL OF HYPERTENSION, 2000, 13 (12) :1263-1267

[9] Polymorphism of the promoter region of prostacyclin synthase gene is not related to essential hypertension [J].

Nakayama, T ;

Soma, M ;

Takahashi, Y ;

Rehemudula, D ;

Tobe, H ;

Sato, M ;

Uwabo, J ;

Kunimoto, M ;

Izumi, Y ;

Kanmatsuse, K .

AMERICAN JOURNAL OF HYPERTENSION, 2001, 14 (05) :409-411

[10] Functional deletion mutation of the 5′-flanking region of type A human natriuretic peptide receptor gene and its association with essential hypertension and left ventricular hypertrophy in the Japanese [J].

Nakayama, T ;

Soma, M ;

Takahashi, Y ;

Rehemudula, D ;

Kanmatsuse, K ;

Furuya, K .

CIRCULATION RESEARCH, 2000, 86 (08) :841-845