Treatment of Arterial Remodeling in Essential Hypertension

被引：62

作者：

Briet, Marie ^{[1
,2
]}

Schiffrin, Ernesto L. ^{[3
,4
]}

机构：

[1] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France

[2] Univ Paris 05, INSERM, CIC 9201, Fac Med, F-75015 Paris, France

[3] Sir Mortimer B Davis Jewish Hosp, Dept Med, B-127,3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada

[4] McGill Univ, Lady Davis Inst Med Res, Montreal, PQ, Canada

来源：

CURRENT HYPERTENSION REPORTS | 2013年 / 15卷 / 01期

基金：

加拿大健康研究院;

关键词：

Eutrophic remodeling; Hypertrophic remodeling; Large elastic and small resistance arteries; Endothelial dysfunction; Arterial stiffness; Pulse wave velocity; PWV; Pharmacological modulation; Angiotensin converting enzyme inhibitors; ACEI; Angiotensin receptor blockers; ARB; Mineralocorticoid; Aldosterone; Spironolactone; Eplerenone; Calcium channel blockers; Diuretics; Blood pressure; Cardiovascular remodeling; Hypertension; SUBCUTANEOUS SMALL ARTERIES; PULSE-WAVE VELOCITY; MAJOR CARDIOVASCULAR EVENTS; SMALL-RESISTANCE ARTERIES; BLOOD-PRESSURE REDUCTION; SMALL-VESSEL DISEASE; ALL-CAUSE MORTALITY; TO-LUMEN RATIO; AORTIC STIFFNESS; STRUCTURAL ALTERATIONS;

D O I：

10.1007/s11906-012-0325-0

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis. Longitudinal follow-up of hypertensive patients has shown that large arterial stiffness decreases partly independently of blood pressure reduction, suggesting specific pharmacological effects of antihypertensive therapy. Inhibitors of the renin-angiotensin-aldosterone system are among the agents that have been shown to affect vascular remodeling to a greater degree. Lifestyle modifications, including exercise and weight reduction, also improve large and small vascular remodeling. New antihypertensive drugs, including neprilysin inhibitors associated with an angiotensin receptor blocker, aldosterone synthase inhibitors and new devices such as renal denervation and baroreceptor stimulation, may exert beneficial effects on vascular remodeling and are currently under evaluation.

引用

页码：3 / 9

页数：7

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