Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK-912:: an O-analogue of the Pictet-Spengler reaction

被引：10
作者：
Albaneze-Walker, J [1 ]
Rossen, K [1 ]
Reamer, RA [1 ]
Volante, RP [1 ]
Reider, PJ [1 ]
机构：
[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期
关键词：
D O I：
10.1016/S0040-4039(99)00840-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet-Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：4917 / 4920
页数：4
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