Biological Roles of Liver X Receptors in Immune Cells

被引:36
作者
Pascual-Garcia, Monica [1 ]
Valledor, Annabel F. [1 ]
机构
[1] Univ Barcelona, Sch Biol, Dept Physiol & Immunol, Nucl Receptor Grp, E-08028 Barcelona, Spain
关键词
LXR; Transrepression; Inflammation; Gene expression; INFLAMMATORY RESPONSE GENES; FACTOR-KAPPA-B; NUCLEAR RECEPTOR; LXR-ALPHA; AGONIST TREATMENT; TARGET GENE; MEDIATES TRANSREPRESSION; SIGNALING PATHWAYS; HORMONE RECEPTORS; LIPID HOMEOSTASIS;
D O I
10.1007/s00005-012-0179-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively the expression of a variety of target genes, many of which are involved in lipid and glucose metabolism. In the last few years, new targets of LXR activation have been identified with roles in the modulation of immune responses. Moreover, LXRs mediate repression of inflammatory pathways through mechanisms collectively known as transrepression. Here, we revise recent findings on the impact of LXR activation on immune responses, with an emphasis on advances in the understanding of the molecular mechanisms that mediate these effects.
引用
收藏
页码:235 / 249
页数:15
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