Inner ear progenitor cells can be generated in vitro from human bone marrow mesenchymal stem cells
被引:3
作者:
Boddy, Sarah L.
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机构:
Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Boddy, Sarah L.
[1
,2
]
Chen, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Chen, Wei
[1
,2
]
Romero-Guevara, Ricardo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Romero-Guevara, Ricardo
[1
,2
]
Kottam, Lucksy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Acad Unit Bone Biol, Mellanby Ctr Bone Res, Sch Med, Sheffield S10 STA, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Kottam, Lucksy
[3
]
Bellantuono, Illaria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Acad Unit Bone Biol, Mellanby Ctr Bone Res, Sch Med, Sheffield S10 STA, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Bellantuono, Illaria
[3
]
Rivolta, Marcelo N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
Rivolta, Marcelo N.
[1
,2
]
机构:
[1] Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
[3] Univ Sheffield, Acad Unit Bone Biol, Mellanby Ctr Bone Res, Sch Med, Sheffield S10 STA, S Yorkshire, England
Aim: Mouse mesenchymal stem cells (MSCs) can generate sensory neurons and produce inner ear hair cell-like cells. An equivalent source from humans is highly desirable, given their potential application in patient-specific regenerative therapies for deafness. In this study, we explored the ability of human MSCs (hMSCs) to differentiate into otic lineages. Materials & methods: hMSCs were exposed to culture media conditioned by human fetal auditory stem cells. Results: Conditioned media induced the expression of otic progenitor markers PAX8, PAX2, GATA3 and SOX2. After 4 weeks, cells coexpressed ATOH1, MYO7A and POU4F3 (indicators of hair cell lineage) or neuronal markers NEUROG1, POU4F1 and NEFH. Inhibition of WNT signaling prevented differentiation into otic progenitors, while WNT activation partially phenocopied results seen with the conditioned media. Conclusion: This study demonstrates that hMSCs can be driven to express key genes found in the otic lineages and thereby promotes their status as candidates for regenerative therapies for deafness.
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Bae, Keum Seok
;
Park, Joon Beom
论文数: 0引用数: 0
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机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Park, Joon Beom
;
Kim, Hyun Soo
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Hematooncol, Wonju 220701, South Korea
FCB Pharmnicell Co Ltd, Songnam, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Kim, Hyun Soo
;
Kim, Dae Sung
论文数: 0引用数: 0
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机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Kim, Dae Sung
;
Park, Dong Jun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Otorhinolaryngol, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Park, Dong Jun
;
Kang, Seong Joon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Baxter, MA
;
Wynn, RF
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wynn, RF
;
Jowitt, SN
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Jowitt, SN
;
Wraith, JE
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机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wraith, JE
;
Fairbairn, LJ
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h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Fairbairn, LJ
;
Bellantuono, I
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机构:
Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, EnglandRoyal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Chen, Wei
;
Johnson, Stuart L.
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h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Johnson, Stuart L.
;
Marcotti, Walter
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h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Marcotti, Walter
;
Andrews, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Andrews, Peter W.
;
Moore, Harry D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Moore, Harry D.
;
Rivolta, Marcelo N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
机构:
Chonnam Natl Univ, Sch Med, Dept Otolaryngol, Kwangju 501757, South KoreaChonnam Natl Univ, Sch Med, Dept Otolaryngol & Head & Neck Surg, Res Inst Med Sci, Kwangju 501757, South Korea
Cho, Yong-Bum
;
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Cho, Hyong-Ho
;
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机构:
Jang, Sujeong
;
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机构:
Jeong, Han-Seong
;
Park, Jong-Seong
论文数: 0引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Sch Med, Dept Physiol, Kwangju 501757, South Korea
Chonnam Natl Univ, Ctr Biomed Human Resources, Brain Korea Project 21, Kwangju 501757, South KoreaChonnam Natl Univ, Sch Med, Dept Otolaryngol & Head & Neck Surg, Res Inst Med Sci, Kwangju 501757, South Korea
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Bae, Keum Seok
;
Park, Joon Beom
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Park, Joon Beom
;
Kim, Hyun Soo
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Hematooncol, Wonju 220701, South Korea
FCB Pharmnicell Co Ltd, Songnam, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Kim, Hyun Soo
;
Kim, Dae Sung
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Kim, Dae Sung
;
Park, Dong Jun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Otorhinolaryngol, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
Park, Dong Jun
;
Kang, Seong Joon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South KoreaYonsei Univ, Wonju Coll Med, Dept Surg, Wonju 220701, South Korea
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Baxter, MA
;
Wynn, RF
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wynn, RF
;
Jowitt, SN
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Jowitt, SN
;
Wraith, JE
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Wraith, JE
;
Fairbairn, LJ
论文数: 0引用数: 0
h-index: 0
机构:Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
Fairbairn, LJ
;
Bellantuono, I
论文数: 0引用数: 0
h-index: 0
机构:
Royal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, EnglandRoyal Manchester Childrens Hosp, Giving Living Postgrad Ctr, Stem Cell Res Grp, Manchester M27 4HA, Lancs, England
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Chen, Wei
;
Johnson, Stuart L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Johnson, Stuart L.
;
Marcotti, Walter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Marcotti, Walter
;
Andrews, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Andrews, Peter W.
;
Moore, Harry D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Moore, Harry D.
;
Rivolta, Marcelo N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, EnglandUniv Sheffield, Ctr Stem Cell Biol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
机构:
Chonnam Natl Univ, Sch Med, Dept Otolaryngol, Kwangju 501757, South KoreaChonnam Natl Univ, Sch Med, Dept Otolaryngol & Head & Neck Surg, Res Inst Med Sci, Kwangju 501757, South Korea
Cho, Yong-Bum
;
论文数: 引用数:
h-index:
机构:
Cho, Hyong-Ho
;
论文数: 引用数:
h-index:
机构:
Jang, Sujeong
;
论文数: 引用数:
h-index:
机构:
Jeong, Han-Seong
;
Park, Jong-Seong
论文数: 0引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Sch Med, Dept Physiol, Kwangju 501757, South Korea
Chonnam Natl Univ, Ctr Biomed Human Resources, Brain Korea Project 21, Kwangju 501757, South KoreaChonnam Natl Univ, Sch Med, Dept Otolaryngol & Head & Neck Surg, Res Inst Med Sci, Kwangju 501757, South Korea