Parallel synthesis of a bis-triazoles library as psammaplin A analogues: A new wave of antibiofilm compounds?

被引：6
作者：
Andjouh, Sofyane [1 ]
Blache, Yves [1 ]
机构：
[1] Univ Toulon & Var, MAPIEM, Toulon, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2019年 / 29卷 / 04期
关键词：
Anti-biofilm; 1,2,3-Triazole; Psammaplin A; Click chemistry; MARINE NATURAL-PRODUCTS; ANTI-BIOFILM COMPOUNDS; CLICK-BASED SYNTHESIS; ANTIFOULING COMPOUNDS; DISCOVERY; COLONIZATION; SPONGE;
D O I：
10.1016/j.bmcl.2018.12.047
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of psammaplin A analogues is described. Screening for antibiofilm activity of the targeted library afford some interesting elements in terms of structure-activity relationships. Some compounds exhibited EC50 in the range of ampicillin against three strains of gramnegative bacteria without toxic effect.
引用
收藏
页码：614 / 618
页数：5
相关论文
共 34 条
[1]   Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies [J].
Andjouh, S. ;
Blache, Y. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (24) :5762-5766
[2]   Screening of bromotyramine analogues as antifouling compounds against marine bacteria [J].
Andjouh, Sofyane ;
Blache, Yves .
BIOFOULING, 2016, 32 (08) :871-881
[3]   Exploitation of marine algae: biogenic compounds for potential antifouling applications [J].
Bhadury, P ;
Wright, PC .
PLANTA, 2004, 219 (04) :561-578
[4]   Identification of Bacterial Strains Isolated from the Mediterranean Sea Exhibiting Different Abilities of Biofilm Formation [J].
Brian-Jaisson, Florence ;
Ortalo-Magne, Annick ;
Guentas-Dombrowsky, Linda ;
Armougom, Fabrice ;
Blache, Yves ;
Molmeret, Maelle .
MICROBIAL ECOLOGY, 2014, 68 (01) :94-110
[5]   Antifouling activity of commercial biocides vs. natural and natural-derived products assessed by marine bacteria adhesion bioassay [J].
Camps, Mercedes ;
Briand, Jean-Francois ;
Guentas-Dombrowsky, Linda ;
Culioli, Gerald ;
Bazire, Alexis ;
Blache, Yves .
MARINE POLLUTION BULLETIN, 2011, 62 (05) :1032-1040
[6]   Antifouling marine natural products [J].
Fusetani, Nobuhiro .
NATURAL PRODUCT REPORTS, 2011, 28 (02) :400-410
[7]   Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology [J].
Gerwick, William H. ;
Moore, Bradley S. .
CHEMISTRY & BIOLOGY, 2012, 19 (01) :85-98
[8]   Biofilms and deteriorations of materials: From analysis of the phenomenon to prevention strategies [J].
Haras, D. .
MATERIAUX & TECHNIQUES, 2005, 93
[9]  
Hou J, EXP OP DRUG DISC, V7, P489
[10]  
Huisgen R., 1984, 1, V1, P1
1234