PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction

被引：4

作者：

Slart, Riemer H. J. A. ^{[1
]}

Glauche, Julius ^{[1
,2
]}

Golestani, Reza ^{[1
]}

Zeebregts, Clark J. ^{[3
]}

Jansen, Jan W. ^{[1
,2
]}

Dierckx, Rudi A. J. O. ^{[1
,5
]}

Oudkerk, Matthijs ^{[4
]}

Willems, Tineke P. ^{[4
]}

Glaudemans, Andor W. J. M. ^{[1
]}

Boersma, Hendrikus H. ^{[1
]}

Tio, Rene A. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Div Vasc Surg, Dept Surg, NL-9700 RB Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, NL-9700 RB Groningen, Netherlands

[5] Ghent Univ Hosp, Dept Nucl Med, Ghent, Belgium

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2012年 / 39卷 / 06期

关键词：

Myocardial infarction; Left ventricular function; Myocardial perfusion imaging; Cardiac MRI; CORONARY MICROVASCULAR DYSFUNCTION; IDIOPATHIC DILATED CARDIOMYOPATHY; GENE-THERAPY; BONE-MARROW; RESERVE; APOPTOSIS; DISEASE;

D O I：

10.1007/s00259-012-2085-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively. Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress N-13-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening. Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p < 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p < 0.001). This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI.

引用

页码：1065 / 1069

页数：5

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