Time series analysis of parkinson's disease, huntington's disease and amyotrophic lateral sclerosis

The aim of this paper is to study the (clinical) time-series data of three diseases with complex dynamics-Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. For this purpose, first all of the time series data are embedded in a vector space with suitable dimension and then the correlation dimension of the above mentioned diseases is estimated. The results are also compared with healthy control subjects. At the next step, existence of chaotic behavior in these diseases is investigated by means of the so-called 0-1 test. The simulations show that none of the diseases under consideration are chaotic. (C) 2010 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of the Guest Editor.