The role of BAFF in the progression of rheumatoid arthritis

被引：79
作者：
Wei, Fang [1 ,2 ]
Chang, Yan [1 ]
Wei, Wei [1 ]
机构：
[1] Anhui Med Univ, Anhui Collaborat Innovat Ctr Antiinflammatory & I, Key Lab Antiinflammatory & Immune Med, Inst Clin Pharmacol,Minist China, Hefei 230032, Peoples R China
[2] Bengbu Med Coll, Dept Pharm, Bengbu 233000, Peoples R China
来源：
CYTOKINE | 2015年 / 76卷 / 02期
关键词：
Rheumatoid arthritis; Immune cells; B cell activating factor; BAFF-R; TACI; BCMA; B-LYMPHOCYTE STIMULATOR; CELL-ACTIVATING FACTOR; FIBROBLAST-LIKE SYNOVIOCYTES; NF-KAPPA-B; HUMAN MONOCLONAL-ANTIBODY; TNF FAMILY BAFF; INADEQUATE RESPONSE; PHASE-II; TACI-IG; EXPRESSION;
D O I：
10.1016/j.cyto.2015.07.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and are correlated with the level of disease activity. As an innate cytokine mediator, BAFF affects the immune response of the synovial microenvironment. In this review, we consider recent observations of BAFF and its receptors in RA progression, as well as the effects of BAFF on the cell-cell interactions network. We also summarize the clinical development of BAFF antagonists for the treatment of RA. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：537 / 544
页数：8
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