Viral Hepatitis B, C Infection and Genotype Distribution among Cholangiocarcinoma Patients in Northeast Thailand

被引：16

作者：

Barusrux, Sahapat ^{[1
]}

Nanok, Chaiyachet ^{[4
]}

Bhudhisawasdi, Vajarabhongsa ^{[2
]}

Pairojkul, Chawalit ^{[3
]}

Poovorawan, Yong ^{[5
]}

机构：

[1] Khon Kaen Univ, Fac Associated Med Sci, Dept Clin Immunol & Transfus Med, Ctr Res & Dev,Med Diagnost Labs, Khon Kaen, Thailand

[2] Khon Kaen Univ, Fac Med, Liver Fluke & Cholangiocarcinoma Res Ctr, Dept Surg, Khon Kaen, Thailand

[3] Khon Kaen Univ, Fac Med, Liver Fluke & Cholangiocarcinoma Res Ctr, Dept Pathol, Khon Kaen, Thailand

[4] Khon Kaen Univ, Khon Kaen, Thailand

[5] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Bangkok 10330, Thailand

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷

关键词：

Cholangiocarcinoma; HBV; HCV; northeast Thailand; INTRAVENOUS-DRUG-USERS; INTRAHEPATIC CHOLANGIOCARCINOMA; VIRUS GENOTYPES; BLOOD-DONORS; RISK-FACTORS; UNITED-STATES; EXTRAHEPATIC CHOLANGIOCARCINOMA; HEPATOCELLULAR-CARCINOMA; HIGH PREVALENCE; SEROPREVALENCE;

D O I：

10.7314/APJCP.2012.13.KKSuppl.83

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prevalence of HBV and HCV infection among 295 cholangiocarcinoma (CCA) patients in northeast Thailand was analyzed. Hepatitis B surface antigen (HBsAg) was detected in 8.8% (26/295 cases) and antibodies to HCV (anti-HCV) in 2.7% (8/295 cases) of CCA cases. Screening for HBV DNA was performed in 15 of 26 HBV seropositive cases and genotypes could be determined in all 15. HBV genotypes C and B were detected in 73.3% (11/15 cases) and 26.7% (4/15 cases), respectively. HCV RNA was detected in 87.5% (7/8 cases) of anti-HCV positive cases. Specifically, 57.1% (4/7 cases) were HCV genotype 1a and 42.9% (3/7 cases) were HCV genotype 3a. The prevalence of infection and genotype distribution of both HCV and HBV among CCA in northeast Thailand is comparable to that in the general population, suggesting that HCV and HBV infections are, if at all, not serious risk factors for CCA.

引用

页码：83 / 87

页数：5

共 38 条

[1] Seroprevalence and Genotype of Hepatitis C Virus among Immigrant Workers from Cambodia and Myanmar in Thailand [J].

Akkarathamrongsin, Srunthron ;

Praianantathavorn, Kesmanee ;

Hacharoen, Nisachol ;

Theamboonlers, Apiradee ;

Tangkijvanich, Pisit ;

Poovorawan, Yong .

INTERVIROLOGY, 2011, 54 (01) :10-16

[2] Geographic Distribution of Hepatitis C Virus Genotype 6 Subtypes in Thailand [J].

Akkarathamrongsin, Srunthron ;

Praianantathavorn, Kesmanee ;

Hacharoen, Nisachol ;

Theamboonlers, Apiradee ;

Tangkijvanich, Pisit ;

Tanaka, Yasuhito ;

Mizokami, Masashi ;

Poovorawan, Yong .

JOURNAL OF MEDICAL VIROLOGY, 2010, 82 (02) :257-262

[3] ANALYSIS OF HEPATITIS-C VIRUS ISOLATES AMONG HEALTHY BLOOD-DONORS AND DRUG-ADDICTS IN CHIANG-MAI, THAILAND [J].

APICHARTPIYAKUL, C ;

CHITTIVUDIKARN, C ;

MIYAJIMA, H ;

HOMMA, M ;

HOTTA, H .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (09) :2276-2279

[4]

Apichartpiyakul C, 1999, JPN J INFECT DIS, V52, P121

[5]

Barusruk Sahapat, 2006, Southeast Asian Journal of Tropical Medicine and Public Health, V37, P289

[6]

Barusrux S, 1997, J MED ASS THAI, V80, P106

[7]

CHAINUVATI T, 1991, GASTROENTEROL JPN, V26, P176

[8] Hepatitis B seroprevalence in Thailand: 12 years after hepatitis B vaccine integration into the national expanded programme on immunization [J].

Chongsrisawat, Voranush ;

Yoocharoen, Pornsak ;

Theamboonlers, Apiradee ;

Tharmaphornpilas, Piyanit ;

Warinsathien, Porpit ;

Sinlaparatsamee, Supakarn ;

Paupunwatana, Siriraj ;

Chaiear, Kasemporn ;

Khwanjaipanich, Sawan ;

Poovorawan, Yong .

TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2006, 11 (10) :1496-1502

[9] Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case-control study in Italy [J].

Donato, F ;

Gelatti, U ;

Tagger, A ;

Favret, M ;

Ribero, ML ;

Callea, F ;

Martelli, C ;

Savio, A ;

Trevisi, P ;

Nardi, G .

CANCER CAUSES & CONTROL, 2001, 12 (10) :959-964

[10] Risk of Hepatobiliary and Pancreatic Cancers After Hepatitis C Virus Infection: A Population-Based Study of US Veterans [J].

El-Serag, Hashem B. ;

Engels, Eric A. ;

Landgren, Ola ;

Chiao, Elizabeth ;

Henderson, Louise ;

Amaratunge, Harshinie C. ;

Giordano, Thomas P. .

HEPATOLOGY, 2009, 49 (01) :116-123

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