Rituximab pharmacokinetics in children and adolescents with de novo intermediate and advanced mature B-cell lymphoma/leukaemia: a Children's Oncology Group report

被引：30

作者：

Barth, Matthew J. ^{[1
]}

Goldman, Stanton ^{[2
]}

Smith, Lynette ^{[3
]}

Perkins, Sherrie ^{[4
]}

Shiramizu, Bruce ^{[5
]}

Gross, Thomas G. ^{[6
]}

Harrison, Lauren ^{[7
]}

Sanger, Warren ^{[8
]}

Geyer, Mark B. ^{[9
]}

Giulino-Roth, Lisa ^{[10
,11
]}

Cairo, Mitchell S. ^{[7
,12
,13
,14
,15
]}

机构：

[1] SUNY Coll Buffalo, Div Pediat Hematol Oncol, Buffalo, NY 14222 USA

[2] Med City Childrens Hosp, Div Pediat Hematol Oncol, Dallas, TX USA

[3] Univ Nebraska, Coll Publ Hlth, Dept Biostat, Omaha, NE 68182 USA

[4] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[5] Univ Hawaii, Div Pediat Hematol Oncol, Honolulu, HI 96822 USA

[6] Ohio State Univ, Div Pediat Hematol Oncol Blood & Marrow Transplan, Columbus, OH 43210 USA

[7] New York Med Coll, Dept Pediat, Valhalla, NY 10595 USA

[8] Univ Nebraska Med Ctr, Dept Cytogenet, Omaha, NE USA

[9] Harvard Univ, Sch Med, Dept Med, Massachusetts Gen Hosp, Boston, MA USA

[10] Weill Cornell Med Coll, Dept Pediat, Div Pediat Hematol Oncol, New York, NY USA

[11] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA

[12] New York Med Coll, Dept Med, Valhalla, NY 10595 USA

[13] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA

[14] New York Med Coll, Dept Microbiol, Valhalla, NY 10595 USA

[15] New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 162卷 / 05期

基金：

美国国家卫生研究院;

关键词：

non-Hodgkin lymphoma; rituximab; pharmacokinetics; pediatric; CD20; NON-HODGKINS-LYMPHOMA; SERUM CONCENTRATIONS; RISK; IDEC-C2B8;

D O I：

10.1111/bjh.12434

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ANHL01P1 trial was undertaken to determine pharmacokinetics and safety following the addition of rituximab to French-American-British/Lymphome Malins de Burkitt (FAB/LMB96) chemotherapy in 41 children and adolescents with Stage III/IV mature B-cell lymphoma/leukaemia. Patients received rituximab (375mg/m(2)) days -2 and 0 of two induction cycles and day 0 of two consolidation cycles. Highest peak levels were achieved following the second dose of each induction cycle [299 +/- 19 and 384 +/- 25 mu g/ml (Group-B); 245 +/- 31 and 321 +/- 32g/ml (Group-C)] with sustained troughs and t1/2 of 26-29d. Rituximab can be safely added to FAB chemotherapy with high early rituximab peak/trough levels and a long t1/2.

引用

页码：678 / 683

页数：6

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