Phosphine-Catalyzed Stereoselective Tandem Annulation Reaction for the Synthesis of Chromeno[4,3-b]pyrroles

被引：36

作者：

Dai, Zonghao ^{[1
]}

Zhu, Jin ^{[1
]}

Su, Wenbo ^{[1
]}

Zeng, Wuxian ^{[1
]}

Liu, Ziqi ^{[1
]}

Chen, Ming ^{[1
]}

Zhou, Qingfa ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Organ Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 17期

基金：

中国国家自然科学基金;

关键词：

3+2 CYCLOADDITION; 1,3-DIPOLAR CYCLOADDITION; ALLENOATES ACCESS; CONSTRUCTION; DERIVATIVES; ALLENES; CYCLIZATION; ALKYNES;

D O I：

10.1021/acs.orglett.0c02558

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A phosphine-catalyzed tandem cyclization reaction has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives, which contain three consecutive asymmetric centers. The reaction has a good yield, excellent stereoselectivity, and Z/E selectivity. The new method is simple, requires only mild conditions, and shows tolerance for various functional groups. Similarly, this reaction can be catalyzed by a chiral phosphine catalyst to achieve asymmetric synthesis.

引用

页码：7008 / 7012

页数：5

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