An animal model of capsular infarct: Endothelin-1 injections in the rat

被引：65
作者：
Frost, SB
Barbay, S
Mumert, ML
Stowe, AM
Nudo, RJ
机构：
[1] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA
[2] Univ Kansas, Med Ctr, Mental Retardat Res Ctr, Kansas City, KS 66160 USA
[3] Univ Kansas, Med Ctr, Landon Ctr Aging, Kansas City, KS 66160 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2006年 / 169卷 / 02期
关键词：
capsular-infarct; white-matter; endothelin-1; animal model;
D O I：
10.1016/j.bbr.2006.01.014
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In this study stereotaxic injections of the vasoconstrictive peptide endothelin-1 (ET-1) were used to create infarcts in the white matter of the internal capsule underlying sensorimotor cortex in rats. Resulting deficits were assessed using established sensorimotor tests conducted on each rat before and after the ET1-induced infarct. After a 14-day survival period, histological examination revealed tissue necrosis and demyelination in the infarcted white matter of ET1-injected rats, but not saline-injected control rats. Infarcts resulted in measurable sensorimotor deficits in rats that received ET-1 injections. The same sensorimotor tests showed no deficits in surgical-control rats. The present model of white matter infarct should be valuable in examining the underlying mechanisms of subcortical ischemic stroke and to evaluate potential therapeutic interventions. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：206 / 211
页数：6
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